Abstract
ACCORDING to the metabolic studies of Stetten and Boxer1, deuterium is incorporated into liver glycogen in the alloxan diabetic rat at a higher rate and at a greater concentration than that achieved in the normal animal. Their previous studies showed that when glycogen was synthesized directly from dietary glucose in a medium of heavy water it was poor in deuterium, whereas glycogen synthesized from fragments smaller than hexose was rich in deuterium. They concluded that the diabetic animal was able to synthesize more liver glycogen from fragments smaller than hexoses than was the normal, non-diabetic rat.
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References
Stetten, jun., DeW., and Boxer, G. E., J. Biol. Chem., 156, 271 (1944).
Cramer, F., “Paper Chromatography” (Macmillan, 1954).
Partridge, S. M., Nature, 164, 4167 (1949).
Fruton, J. S., and Simmonds, Sofia, “General Biochemistry” (Wiley, 1953).
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MUELLER, I., PHILLIPS, J. Pentose Metabolism in Diabetic and Normal Rats. Nature 179, 1194–1195 (1957). https://doi.org/10.1038/1791194a0
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DOI: https://doi.org/10.1038/1791194a0
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