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Inhibitory Effect of Malonate on the Respiration of Brain Tissue, with Special Reference to the Potassium Effect

Abstract

IT has long been known that, in brain cortex slices, both aerobic glycolysis and respiration are enhanced markedly when potassium chloride (0.1 M) is added to the suspension medium1, this metabolic effect of potassium being peculiar to nervous tissue2 and abolished by grinding the material3. In view of the manner in which the increased aerobic glycolysis and respiration respond to various metabolic poisons such as potassium cyanide, malonate and monoiodoacetate, it seems possible that the type of linkage of these two metabolic routes differs from that under normal conditions4.

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References

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KIMURA, Y., NIWA, T. Inhibitory Effect of Malonate on the Respiration of Brain Tissue, with Special Reference to the Potassium Effect. Nature 171, 881–882 (1953). https://doi.org/10.1038/171881a0

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