Abstract
WE have formulated a structure for the nucleic acids which is compatible with the main features of the X-ray diagram and with the general principles of molecular structure, and which accounts satisfactorily for some of the chemical properties of the substances. The structure involves three intertwined helical polynucleotide chains. Each chain, which is formed by phosphate di-ester groups and linking β-D-ribofuranose or β-D-deoxyribofuranose residues with 3′, 5′ linkages, has approximately twenty-four nucleotide residues in seven turns of the helix. The helixes have the sense of a right-handed screw. The phosphate groups are closely packed about the axis of the molecule, with the pentose residues surrounding them, and the purine and pyrimidine groups projecting radially, their planes being approximately perpendicular to the molecular axis. The operation that converts one residue to the next residue in the polynucleotide chain is rotation by about 105° and translation by 3.4 A.
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PAULING, L., COREY, R. Structure of the Nucleic Acids. Nature 171, 346 (1953). https://doi.org/10.1038/171346a0
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DOI: https://doi.org/10.1038/171346a0
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