Abstract
Neuropsychological deficits are potential side effects of hematopoietic stem cell therapy (HSCT). Systematic data on the long-term course of and therapeutic options for these consequences are limited. One hundred fifty-seven patients were screened for cognitive deficits following HSCT for malignant diseases at an in-patient oncologic rehabilitation clinic. Patients showing evidence of impairment were randomly assigned to one of two training groups: individualized PC-supported training or neuropsychological group therapy. The control group consisted of patients who received no specific training. During in-patient rehabilitation, the results of a comprehensive neuropsychological test battery improved significantly in all three groups, and no specific intervention effects were identified. Neuropsychological deficits were still evident in a subgroup of patients 6 months later. Correlation between neuropsychological testing and patients' self-evaluation of cognitive functioning in daily life was generally low. Sustained attention and verbal-semantic memory played the main role for self-appraisal and in the designation as ‘neuropsychologically impaired’. In conclusion, a substantial number of patients revealed evidence of cognitive deficits a long time after HSCT. There is a need for more studies and for the development of differentiated rehabilitative measures for such therapeutic consequences.
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Acknowledgements
This study was supported by the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF, Berlin, Germany, Grant number 02821) and the German Pension Fund (Deutsche Rentenversicherung-Bund, Berlin, Germany).
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Poppelreuter, M., Weis, J., Mumm, A. et al. Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation. Bone Marrow Transplant 41, 79–90 (2008). https://doi.org/10.1038/sj.bmt.1705884
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DOI: https://doi.org/10.1038/sj.bmt.1705884
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