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Post-Transplant Events

Hair follicle: a reliable source of recipient origin after allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 40, pages 871–874 (2007)Cite this article

Abstract

Blood, buccal swab and hair follicles are among the most commonly used sources for forensic science, parentage testing and personal identification. A total of 29 patients who have had a sustained engraftment from 15 months to 21.5 years after allogeneic hematopoietic stem cell transplantation (HSCT) without rejection, relapse or chronic GVHD involving oral mucosa were enrolled for a chimerism study. PCR-amplified short tandem repeat analyses were conducted per patient every 3 months for at least three consecutive times. The results for blood were all donor type except one who had a mixed chimerism, 14.5 years after receiving a transplant for lymphoma. As for buccal swab, mixed chimerism ranging from 10 to 96% donor origin was noted for 28 recipients except the one who had mixed chimerism of blood and retained total recipient type. In contrast, hair follicles were 100% recipient type for the entire group. It is concluded that the hair follicle is devoid of adult stem cell plasticity and may serve as a reliable source of recipient's origin when pre-transplant DNA fingerprinting or reference DNA is not available for people who have successfully received allogeneic HSCT while in need of a personal identification.

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Acknowledgements

This work was supported by research Grants NSC 95-2745-B-075-007 from the National Science Council, and VGH-95-C-132 from the Taipei Veterans General Hospital, Taipei, Taiwan.

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Author notes

  1. Y C Hong and H M Liu: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Section of Hemato-Oncology, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Y C Hong & C-H Tzeng

  2. Department of Medicine, Section of Transfusion Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan

    H M Liu, P S Chen, Y J Chen, J Y Lyou, H Y Hu, M F Yi, J S Lin & C-H Tzeng

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  1. Y C Hong
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  2. H M Liu
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Correspondence to C-H Tzeng.

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Hong, Y., Liu, H., Chen, P. et al. Hair follicle: a reliable source of recipient origin after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 40, 871–874 (2007). https://doi.org/10.1038/sj.bmt.1705823

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  • DOI: https://doi.org/10.1038/sj.bmt.1705823

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