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Coronary artery spasm after infusion of cryopreserved cord blood cells

Bone Marrow Transplantation volume 40, pages 397–398 (2007)Cite this article

Cord blood cells (CBC) from both related and unrelated donors are being used as a source of haematopoietic stem cells (HSC) in a variety of haematological disorders. The advantages of CBC are the immediate availability, the absence of risk to the donor, the potentially reduced risk of GVHD and a lower need for HLA compatibility between the donor and the recipient. Nevertheless, the CBC content and the HLA disparities have a considerable effect on the final outcome of the transplantation.1

Cryopreservation allows for the long-term storage of CBC. DMSO is the most frequently used cryopreservation agent.2 However, the use of DMSO has been reported to induce complications ranging from nausea, vomiting, abdominal pain to life-threatening cardiac arrhythmias or cardiopulmonary events,3 after infusion of cryopreserved BM or peripheral HSC.

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Authors and Affiliations

  1. Département d’Hématologie et Oncologie Médicale, Hôtel-Dieu, Paris, France

    A D Petropoulou, R Bellochine, J-P Marie & B Rio

  2. Centre de thérapie cellulaire, La Pitié Salpêtrière, Paris, France

    F Norol

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  1. A D Petropoulou
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  2. R Bellochine
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  3. F Norol
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  4. J-P Marie
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  5. B Rio
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Correspondence to A D Petropoulou.

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Petropoulou, A., Bellochine, R., Norol, F. et al. Coronary artery spasm after infusion of cryopreserved cord blood cells. Bone Marrow Transplant 40, 397–398 (2007). https://doi.org/10.1038/sj.bmt.1705735

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