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Autografting

Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen

Bone Marrow Transplantation volume 40, pages 239–243 (2007)Cite this article

Abstract

The role of high-dose therapy and autologous stem cell transplantation (ASCT) for patients with peripheral T-cell lymphoma (PTCL) is poorly defined. Comparisons of outcomes between PTCL and B-cell non-Hodgkin's lymphoma (NHL) have yielded conflicting results, in part due to the rarity and heterogeneity of PTCL. Some retrospective studies have found comparable survival rates for patients with T- and B-cell NHL. In this study, we report our single-center experience of ASCT over one decade using a uniform chemotherapy-only high-dose regimen. Thirty-two patients with PTCL-unspecified (PTCL-u; 11 patients) and anaplastic large-cell lymphoma (21 patients) underwent autologous stem cell transplant, mostly for relapsed or refractory disease. The preparative regimen consisted of busulfan, etoposide and cyclophosphamide. Kaplan–Meier 5-year overall survival (OS) and relapse-free survival (RFS) are 34 and 18%, respectively. These results suggest a poor outcome for patients with PTCL after ASCT, and new therapies for T-cell lymphoma are needed.

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References

  1. The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the international lymphoma study group classification of non-Hodgkin's lymphoma. Blood 1997; 89: 3909–3918.

    Google Scholar 

  2. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink H, Vardiman J et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-airlie house, Virginia, November 1997. J Clin Oncol 1999; 17: 3835–3849.

    Article  CAS  Google Scholar 

  3. Melnyk A, Rodriguez A, Pugh WC, Cabannillas F . Evaluation of the revised European-American lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non-Hodgkin's lymphoma. Blood 1997; 89: 4514–4520.

    CAS  PubMed  Google Scholar 

  4. Lopez-Guillermo A, Cid J, Salar A, Lopez A, Montalban C, Castrillo J et al. Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the REAL classification. Ann Oncol 1998; 9: 849–855.

    Article  CAS  Google Scholar 

  5. Gisselbrecht C, Gaulard P, Lepage E, Coiffier B, Briere J, Haioun C et al. Prognostic significance of T-cell phenotype in aggressive non-Hodgkin's lymphomas. Groupe d′études des lymphomes de l′adulte (GELA). Blood 1998; 92: 76–82.

    CAS  PubMed  Google Scholar 

  6. Rudiger T, Weisenburger DD, Anderson JR, Armitage J, Diebold J, MacLennan K et al. Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the non-Hodgkin's lymphoma classification project. Ann Oncol 2002; 13: 140–149.

    Article  CAS  Google Scholar 

  7. Gascoyne RD, Aoun P, Wu D, Chhanabhai M, Skinnider B, Greiner T et al. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood 1999; 93: 3913–3921.

    CAS  PubMed  Google Scholar 

  8. Falini B, Pileri S, Zinzani PL, Carbone A, Zagonel V, Wolf-Peeters C et al. ALK+ lymphoma: clinico-pathological findings and outcome. Blood 1999; 93: 2697–2706.

    CAS  PubMed  Google Scholar 

  9. Rodriguez J, Caballero MD, Gutierrez A, Marin J, Lahuerta J, Sureda A et al. High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma: the GEL-TAMO experience. Ann Oncol 2003; 14: 1768–1775.

    Article  CAS  Google Scholar 

  10. Vose JM, Peterson C, Bierman PJ, Weisenburger D, Linder J, Harrington D et al. Comparison of high-dose therapy and autologous bone marrow transplantation for T-cell and B-cell non-Hodgkin's lymphomas. Blood 1990; 76: 424–431.

    CAS  PubMed  Google Scholar 

  11. Song KW, Mollee P, Keating A, Crump M . Autologous stem cell transplant for relapsed and refractory peripheral T-cell lymphoma: variable outcome according to pathological subtype. Br J Haematol 2003; 120: 978–985.

    Article  Google Scholar 

  12. Ansell SM, Habermann TM, Kurtin PJ, Witzig T, Chen M, Li C et al. Predictive capacity of the international prognostic factor index in patients with peripheral T-cell lymphoma. J Clin Oncol 1997; 15: 2296–2301.

    Article  CAS  Google Scholar 

  13. Rodriguez J, Munsell M, Yazji S, Hagemeister F, Younes A, Andersson B et al. Impact of high-dose chemotherapy on peripheral T-cell lymphomas. J Clin Oncol 2001; 19: 3766–3770.

    Article  CAS  Google Scholar 

  14. Rodriguez J, Conde E, Gutierrez A, Arranz R, Leon A, Marin J et al. The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: the Spanish Lymphoma and Autologous Transplantation Group experience. Ann Oncol 2007; 18: 652–657.

    Article  CAS  Google Scholar 

  15. Blystad AK, Enblad G, Kvaloy S, Berglund A, Delabie J, Holte H et al. High-dose therapy with autologous stem cell transplantation in patients with peripheral T cell lymphomas. Bone Marrow Transplant 2001; 27: 711–716.

    Article  CAS  Google Scholar 

  16. Jantunen E, Wiklund T, Juvonen E, Putkonen M, Lehtinen T, Kuittinen O et al. Autologous stem cell transplantation in adult patients with peripheral T-cell lymphoma: a nation-wide survey. Bone Marrow Transplant 2004; 33: 405–410.

    Article  CAS  Google Scholar 

  17. Zamkoff KW, Matulis MD, Mehta AC, Beaty MW, Hutchison RE, Gentile TC . High-dose therapy and autologous stem cell transplant does not result in long-term disease-free survival in patients with recurrent chemotherapy-sensitive ALK-negative anaplastic large-cell lymphoma. Bone Marrow Transplant 2004; 33: 635–638.

    Article  CAS  Google Scholar 

  18. Fanin R, Ruiz de Elvira MC, Sperotto A, Baccarani M, Goldstone A . Autologous stem cell transplantation for T and null cell CD30-positive anaplastic large cell lymphoma: analysis of 64 adult and paediatric cases reported to the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 1999; 23: 437–442.

    Article  CAS  Google Scholar 

  19. Copelan E, Penza S, Pohlman B, Avalos B, Goormastic M, Andresen S et al. Autotransplantation following busulfan, etoposide, and cyclophosphamide in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant 2000; 25: 1243–1248.

    Article  CAS  Google Scholar 

  20. Kurzrock R, Ravandi F . Purine analogues in advanced T-cell lymphoid malignancies. Semin Hematol 2006; 43 (2 Suppl 2): S27–S34.

    Article  CAS  Google Scholar 

  21. Enblad G, Hagberg H, Erlanson M, Lundin J, MacDonald A, Repp R et al. A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas. Blood 2004; 103: 2920–2924.

    Article  CAS  Google Scholar 

  22. Talpur R, Apisarnthanarax N, Ward S, Duvic M . Treatment of refractory peripheral T-cell lymphoma with denileukin diftitox (ONTAK). Leuk Lymphoma 2002; 43: 121–126.

    Article  Google Scholar 

  23. Tsimberidou AM, Giles F, Romaguera J, Duvic M, Kurzrock R . Activity of interferon-α and isotretinoin in patients with advanced, refractory lymphoid malignancies. Cancer 2004; 100: 574–580.

    Article  CAS  Google Scholar 

  24. Piekarz RL, Robey R, Sandor V, Bakke S, Wilson W, Dahmoush L et al. Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report. Blood 2001; 98: 2865–2868.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Taussig Cancer Center, Cleveland, OH, USA

    S D Smith, B J Bolwell, L A Rybicki, S Brown, R Dean, M Kalaycio, R Sobecks, S Andresen, E D Hsi, B Pohlman & J W Sweetenham

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  1. S D Smith
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  2. B J Bolwell
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  3. L A Rybicki
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  4. S Brown
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  5. R Dean
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  6. M Kalaycio
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  7. R Sobecks
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  8. S Andresen
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  9. E D Hsi
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  10. B Pohlman
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  11. J W Sweetenham
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Correspondence to S D Smith.

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Smith, S., Bolwell, B., Rybicki, L. et al. Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen. Bone Marrow Transplant 40, 239–243 (2007). https://doi.org/10.1038/sj.bmt.1705712

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