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Pediatric Transplants

Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation

Bone Marrow Transplantation volume 39, pages 89–99 (2007)Cite this article

Abstract

This paper describes the trends in haematopoietic stem cell transplantation (HSCT) activity for children in Europe over the last three decades. We analysed 31 713 consecutive paediatric HSCTs reported by the European Group for Blood and Marrow Transplantation (EBMT) centres between 1970 and 2002. Data were taken from the EBMT registry and were compared according to period and centre category (paediatric or combined). Since 1996, there has been a significant increase in the number of HSCTs performed exclusively by paediatric centres, as well as in the number of alternative donor HSCTs, and in the use of peripheral blood stem cells (P<0.0001). The number of allogeneic HSCTs (allo-HSCTs) for acute lymphoblastic leukaemia, acute myeloblastic leukaemia and chronic myeloid leukaemia remained stable, whereas it increased for myelodysplastic syndromes and lymphomas, and decreased significantly for non-malignant diseases (P<0.0001). Multivariate analysis showed that younger age, human leukocyte antigen genoidentical donors, HSCT performed after 1996 and transplant centres performing more than 10 allo-HSCT/year were all associated with decreased transplant-related mortality (TRM) (P<0.0001). The number of autologus HSCTs (auto-HSCTs) for acute leukaemia decreased significantly, whereas it increased for solid tumours (P<0.0001). Multivariate analysis showed that both auto-HSCT performed before 1996 and paediatric solid tumours (P<0.0001) had higher TRM. Indications for paediatric HSCT have changed considerably during the last seven years. These changes provide tools for decision making in health-care planning and counselling.

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Acknowledgements

We thank all the participating teams listed in the Appendix and the EBMT registry Subcommittee (C Ruiz de Elvira), the EBMT acute leukaemia registry, Roberta Cancedda for data management and Sara Calmanti for her help in preparing the manuscript. Maurizio Miano wrote the manuscript. Myriam Labopin analysed data and assisted in the manuscript preparation. Oliver Hartmann, Emanuele Angelucci, Jacqueline Cornish, Eliane Gluckman, Franco Locatelli, Alain Fischer, Rudolph M Egeler, Reuven Or, Christina Peters, Juan Ortega, Paul Veys, Pierre Bordigoni, Anna Paola Iori and Dietrich Niethammer provided analytic tools and assisted in the manuscript preparation. Vanderson Rocha analysed data and assisted in the manuscript preparation. Giorgio Dini designed the research and assisted in the manuscript preparation. Supported in part by a grant from CARIGE, the Compagnia San Paolo and the Ricerca Finalizzata Ministeriale 2002.

Author information

Authors and Affiliations

  1. Department of Paediatric Haematology and Oncology, IRCSS Giannina Gaslini, Genova, Italy

    M Miano & G Dini

  2. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (ALWP-EBMT), Hôpital Saint Antoine AP/HP, Paris, France

    M Labopin

  3. Department of Paediatric Oncology, Bone Marrow Transplantation Unit, Institut Gustave Roussy, Villejuif, France

    O Hartmann

  4. Department of Haematology, Pesaro Hospital, Pesaro, Italy

    E Angelucci

  5. Department of Haematology, Ospedale A. Businco, Cagliari, Italy

    E Angelucci

  6. Department of Paediatric Oncology and Bone Marrow Transplantation, Bristol Royal Hospital for Children, Bristol, UK

    J Cornish

  7. Department of Haematology and Bone Marrow Transplantation, Hôpital St Louis, Paris, France

    E Gluckman

  8. Department of Paediatric Haematology-Oncology, IRCCS Policlinico San Matteo, Pavia, Italy

    F Locatelli

  9. Department of Immunology and Haematology, Hôpital Necker, Paris, France

    A Fischer

  10. Department of Paediatrics, University Hospital, Leiden, The Netherlands

    R M Egeler

  11. Department of Bone Marrow Transplantation, Hadassah Hebrew University Medical Centre, Ein-Karem, Jerusalem, Israel

    R Or

  12. BMT Unit, St Anna Kinderspital, Wien, Austria

    C Peters

  13. Department of Paediatric Haematology and Oncology, Hospital Vall d’Hebron, Barcelona, Spain

    J Ortega

  14. Bone Marrow Transplantation Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK

    P Veys

  15. Bone Marrow Transplantation Unit, Hôpital d’Enfants, Medicine Infantile, Vandoevre, France

    P Bordigoni

  16. Department of Haematology, Università La Sapienza, Roma, Italy

    A P Iori

  17. Department of Paediatrics, University Hospital, Tubingen, Germany

    D Niethammer

  18. Acute Leukaemia Working Party of the European Bone and Marrow Transplant group (ALWP-EBMT), Hôpital St Louis, Paris, France

    V Rocha

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for the Paediatric Diseases Working Party of the European Group for Blood and Marrow Transplantation

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Correspondence to G Dini.

Appendix

Appendix

List of transplant centres. The total number of transplantations are listed first, followed by the number of allografts/autografts.

*Paediatric centers, #combined centres in which children represented more than 25% of treated patients, °combined centres in which children represented less than 25% of treated patients.

Algeria:

One team, 109 (104/5)

Alger, Centre Pierre et Marie Curie#, CIC 703 RM Hamladji (109, 104/5).

Argentina:

Two teams, 73 (44/29)

Buenos Aires, Antartida Hospital Privado#, CIC 742 L Feldman (72, 43/29) – La Plata, ITMO-Instituto de Transplante de Medula Osea#, CIC 511 JH Milone (1,1/0).

Australia:

Seven teams, 247 (137/110)

Brisbane, Royal Hospital°, CIC 166 (3, 3/0) – Melbourne Victoria, Alfred Hospital°, CIC 595 AP Schwarer (4, 3/1) – Perth Western, Royal Hospital°, CIC 710, RP Herrmann (12, 8/4) – Randwick, Sydney Children's Hospital*, CIC 698 M Vowels, Marcus (17, 17/0) – Sidney, St Vincent's Hospital°, CIC 388 (1, 0/1) – Woodville, The Queen Elizabeth Hosp°, CIC 564 (2, 0/2) – Westmead, The Children's Hospital*, PJ Shaw, CIC 711 (208, 106/102).

Austria:

Eight teams, 683 (402/281)

Graz, University Children's Hospital*, CIC 593, C Urban (91, 51/40) – Innsbruck, University Hospital°, CIC 271, G Gastl (76, 36/40) – Linz, I. Med. Abteilung°, CIC 343, M Fridrik (2, 0/2) – Linz, Elisabethinen-Hospital°, CIC 594, D Lutz (5, 0/5) – Wien, AKH und University°, CIC 227, H Greinix (10, 6/4) – Wien, St Anna Kinderspital*, CIC 528, H Gadner (496, 309/187) – Wien, Hanuschkrankenhaus°, CIC 743, E Koller (2, 0/2) – Wien, Wilhelminenspital°, CIC 828, L Heinz (1, 0/1).

Republic of Belarus:

Two teams, 33 (24/9)

Minsk, Belorussian Centre for Paediatric Oncol. and Hemat*, CIC 591, O Aleinikova (17, 17/0) – Minsk, Hospital No. 9°, CIC 801, A Uss (°16, 7/9).

Belgium:

12 teams, 656 (415/241)

Antwerp, Antwerp University Hospital°, CIC 339, W Schroyens (7, 3/4) – Antwerp, AZ Middelheim°, CIC 783, R de Bock (4, 0/4) – Brugge, AZ Sint Jan°, CIC 506, D Selleslag (4, 1/3) – Brussels, Children's Univ Hospital*, CIC 215, C Devalck (143, 92; 51) – Brussels, Cliniques Universitaires St Luc°, CIC 234, A Ferrant (172, 105/67) – Brussels, U.L.B. Hopital Erasme°, CIC 596, W Fereman (2, 0/2) – Brussels, University Hospital VUB°, CIC 630, R Schots (48, 34/14) – Charleroi, CHNDRF°, CIC 349, A Marc (2, 0/2) – Gent, Paediatric Clinic C. Hooft*, CIC 744, G Laureys (73, 62/11) – Virga Jesse Hospital°, CIC 632 G Bries (2, 0/2) – Leuven, University Hospital*, CIC 209, A Uyttebroeck (131, 77/54) – Liege, University of Liege°, CIC 726, Y Beguin (68, 41/27).

Brazil:

Two teams, 58 (55/3)

Campinas, Univ. Est. Zeferino Vaz#, CIC 374, C De Souza (57, 55/2) – Rio de Janeiro, Hospital Univ. Clementino Fragafilho°, CIC 179, A Maiolino (1, 0/1).

Bulgaria:

One team, 31 (5/26)

Sofia, University Hospital Queen Johanna#, CIC 346, D Bobev (31, 5/26).

Canada:

One team, 3 (3/0)

Ottawa, General Hospital°, CIC 351, L Huebsch (3, 3/0).

China:

Three teams, 6 (0/6)

Beijing, Bey Tai Ping Lu Hospital°, CIC 522 (2, 0/2) – Tiangiing, Chinese Academy Of Medical Sciences°, CIC 550 (3, 0/3) – Lanzhou, General Hospital°, CIC 569 (1, 0/1).

Croatia:

One team, 92 (31/61)

Zagreb, University Hospital Center Rebro°, CIC 302, B Labar (92, 31/61).

Czech Republic:

Two teams, 178 (161/17)

Pilsen, Charles University Hospital°, CIC 718, V Koza (10, 8/2) – Prague, University Hospital Motol*, CIC 656, J Stary (168, 153/15).

Denmark:

Two teams, 344 (281/63)

Aarhus, University Dept of Hemat Arhus Amtssygehus#, CIC 634, E Segel (9, 0/9) – Copenhagen, Rigshospitalet*, CIC 206, C Heilmann (335, 281/54).

Egypt:

One team, 2(0/2)

Cairo University Oncology Centre°, CIC 365, H Azim (2, 0/2).

Estonia:

One team, 25 (3/22)

Tartu, University Clinics°, CIC 746, A Kaare (25, 3/22).

Finland:

Six teams, 407 (233/174)

Helsinki, Hospital for Children & Adolescents*, CIC 219, K Vettenranta (341, 204/137) – Helsinki, University Central Hospital°, CIC 515, T Ruutu (10, 10/0) – Helsinki, University Central Hospital°, CIC 833, R Janes (3, 0/3) – Kuopio, University Hospital°, CIC 396, T Nousiainen (1, 0/1) – Tampere, University Hospital*, CIC 635, M Arola (26, 0/26) – Turku, University Hospital°, CIC 225, K Remes (26, 19/7).

France:

63 teams, 7414 (3457/3957)

Angers, CHRU°, CIC 650, N Ifrah (61, 12/49) – Angers, Centre Paul Papin°, CIC 956 (1, 0/1) – Besancon, Hopital Jean Minjoz°, CIC 233, P Herve (271, 120/151) – Bordeaux, Groupe Hospitalier Pellegrin-Enfants°, CIC 978 (2, 0/2) – Brest, Hôpital Augustin-Morvan°, CIC 659, JF Abgrall (19, 1/18) – Caen, University Hospital°, CIC 251 O Reman (23, 15/8) – Caen, CHU Francois Baclesse°, CIC 951 (5, 0/5) – Clamart, Hôpital Percy°, CIC 665, T de Revel (3, 2/1) – Clermont-Ferrand, Hotel Dieu CHU#, CIC 273, JO Bay (298, 97/201) – Clichy, Hôpital Beaujon°, CIC 662 (4, 0/4) – Creteil, Hôpital Henri Mondor°, CIC 252, C Cordonnier (184, 154/30) – Dijon, Hôpital d'Enfants CHU de Dijon°, CIC 667, D Caillot (9, 1/8) – Grenoble, Hôpital A Michallon°, CIC 270, F Garban (85, 37/48) – Lille, Hôpital Claude Huriez°, CIC 277, JP Jouet (110, 95/15) – Lille, Centre Oscar Lambret#, CIC 972, AS Defachelles (45, 0/45) – Limoges, CHRU°, CIC 977, D Bordessoule (1, 0/1) – Lyon, Centre Leon Berard#, CIC 241, T Philip (330, 9/321) – Lyon, Hôpital E. Herriot°, CIC 671, M Michallet (46, 38/8) – Lyon, Hôpital Debrousse*, CIC 806, Y Bertrand (355, 302/53) – Marseille, Institut Paoli Calmettes°, CIC 230 D Blaise (196, 80/116) – Marseille, Hôpital d’Enfants de la Timone*, CIC 301, C Coze (481, 209/272) – Montpellier, University Hôspital°, CIC 926, JF Rossi (10, 3/7) – Montpellier, Hôpital Arnaud de Villeneuve*, CIC 988 (8, 4/4) – Mullhouse, Hôpital Emile Muller°, CIC 944 (4, 0/4) – Nancy, Hôpital de Nancy°, CIC 249 (22, 11/11) – Nantes, Hotel Dieu°, CIC 253, JL Harousseau (218, 132/86) – Nice, Hôpital de l’Archet°, CIC 523, N Gratecos (41, 26/15) – Nice, Centre Antoine Lacassagne°, CIC 973 (6, 0/6) – Paris, Hôpital Necker°, CIC 160, A Buzyn (23, 17/6) – Paris, Hôpital Necker*, CIC 201, A Fischer (623, 604/19) – Paris, Hôpital St Louis#, CIC 207, E Gluckman (665, 656/9) – Paris, Hôpital St Antoine°, CIC 213, NC Gorin (36, 10/26) – Paris, Hotel Dieu°, CIC 222, B Rio (25, 17/8) – Paris, Pitie-Salpetriere°, CIC 262, V Leblond (16, 13/3) – Paris, Hôpital Cochin°, CIC 280, F Dreyfus (7, 4/3) – Paris, Hôpital Trousseau*, CIC 675 (145, 13/132) – Paris, Institute Curie*, CIC 702, J Michon (374, 3/371) – Paris, Hôpital Laennec°, CIC 723 (3, 0/3) – Paris, Hôpital Tenon°, CIC 747, JP Lotz (4, 0/4) – Paris, Hôpital St Louis*, CIC 748, A Baruchel (127, 10/117) – Paris, Hôpital St Louis°, CIC 805, N Mounier (8, 0/8) – Paris, Hotel Dieu°, CIC 876 (1, 0/1) – Paris, Hôpital St Louis°, CIC 960, L Degos (1, 0/1) – Paris, Institut Universitaire d’Hématologie Hôpital St Louis°, CIC 967, L Degos (5, 0/5) – Pessac, Hôpital Haut-Leveque°, CIC 267, J Reiffers (135, 93/42) – Poitiers, Hopital La Miletrie°, CIC 264, F Guilhot (67, 52/15) – Pontoise, Centre Hospit. René Dubos°, CIC 961, Y Kerneis (2, 0/2) – Pontoise, Centre Hospitalier René Dubos°, CIC 971, Y Kerneis (1,0/1) – Reims, Hôpital Robert Debre°, CIC 959, JP Vilque (14, 0/14) – Rennes, Hôpital Pontchaillou°, CIC 661 (55, 23/32) – Rouen, Hopital Charles Nicolle*, CIC 932, JP Vannier (169, 88/81) – Rouen, Centre Rouen Becquerel°, CIC 941 (13, 2/11) – St Cloud, Centre Rene Huguenin°, CIC 551, M Janvier (3, 0/3) – St Etienne, Hôpital Nord#, CIC 250 (113, 65/48) – Strasbourg, Hopital de Hautepierre°, CIC 672 (28, 19/9) – Strasbourg, Hopital de Hautepierre*, CIC 953 (101, 62/39) – Toulouse, Hôpital de Purpan°, CIC 624, M Attal (62, 21/41) – Toulouse, CHU de Purpan*, CIC 952, H Rubie (89, 45/44) – Tours, Hôpital Bretonneau°, CIC 272, P Colombat (74, 0/74) – Vandoeuvre, Hôpital d'Enfants*, CIC 676, P Bordigoni (362, 209/153) – Villejuif, Institut Gustave Roussy*, CIC 503, O Hartmann (1115, 10/1105) – Villejuif, Groupe Hospitalier Paul-Brousse°, CIC 567 (6, 1/5) – Villejuif, Institut Gustave Roussy°, CIC 666, JH Bourhis (104, 72/32).

Germany:

59 teams, 2975 (2076/899)

Augsburg, Klinikum Augsburg°, CIC 152, M Sandherr (3,1/2) – Berlin, Campus Charité Mitte°, CIC 293, W Siegert (37, 23/14) – Berlin, Otto-Heubner-Centrum*, CIC 336, W Ebell (158, 137/21) – Berlin, Robert-Rössle-Klinik Helios Kilinkum°, CIC 518, M Hildebrandt (10, 0/10) – Berlin, Charité Universitätsmedizin Berlin°, CIC 807, R Arnold (9, 7/2) – Bonn, Rheinische Friedrich Wilhelms Universität°, CIC 134 (13, 0/13) – Bremen, Medizinische Klinik I°, CIC 602, H Rasche (5, 0/5) – Cologne, University of Cologne°, CIC 534, C Scheid (13, 1/12) – Cottbus, Carl-Thiem Klinikum°, CIC 102 (3, 0/3) – Dresden, Carus Klinik und Poliklinik fur Kinder und Jugendmedizin*, CIC 808, M Suttorp (36, 23/13) – Dusseldorf, Heinrich Heine Universität°, CIC 390, H Kobbe (7, 3/4) – Dusseldorf, Klinik für Kinder. Onkol. Hämat. und Immun.*, CIC 651, D Dilloo (173, 115/58) – Erlangen, Universitaetsklinik Erlangen/Nürnberg*, CIC 154 (21, 12/9) – Erlangen, Univ. of Erlangen*, CIC 809, W Holter (55, 21/34) – Essen, Universitaetsklinikum°, CIC 126 (1, 0/1) – Essen, Universitaetsklinikum°, CIC 127 (2, 0/2) – Essen, University Hospital*, CIC 259, B Kremens (139, 107/32) – Essen, Kliniken Essen Süd°, CIC 784, W Heit (2, 0/2) – Frankfurt, University Children's Hospital*, CIC 138, T Klingebiel (14, 11/3) – Frankfurt, Klinik Johann W. Goethe Univer.°, CIC 297, D Hoelzer (14, 5/9) – Freiburg, University Children's Hospital*, CIC 810, C Niemeyer (84, 76/8) – Giessen, Univ. Children's Hosp.*, CIC 326, A Reiter (4, 3/1) – Gottingen, Universitätsklinikum°, CIC 552, B Glass (5, 0/5) – Greifswald, Ernst-Moritz-Arndt-Univer. Greifswald°, CIC 530, G Doelken (2, 0/2) – Halle, Martin-Luther-Univ.*, CIC 654, R Schobess (17, 9/8) – Hamburg, Allgemeines Krankenhaus Altona°, CIC 366, H Salwender (3, 0/3) – Hamburg, University Hospital Eppendorf°, CIC 614, AR Zander (155, 113/42) – Hamburg, Universitätsklinikum Eppendorf°, CIC 673, C Bokemeyer (2, 0/2) – Hannover, Medical School of Hannover*, CIC 295, K Welte (178, 127/51) – Heidelberg, University of Heidelberg°, CIC 524, P Dreger (20, 1/19) – Homburg, University Hospital°, CIC 785, J Schubert (38, 20/18) – Idar-Oberstein, Klinik für Knochenmarktransplantation°, CIC 592, AA Fauser (55, 42/13) – Jena, University Hospital*, CIC 750, F Zintl (211, 125/86) – Kiel, UKSH°, CIC 256, M Schrappe (91, 75/16) – Koln, Universitat zu Koln*, CIC 631, F Berhtol (286, 263/23) – Leipzig, University of Leipzig°, CIC 389, D Niederwieser (11, 2/9) – Lubeck, Universität zu Lübeck*, CIC 367, P Bucsky (3, 0/3) – Magdeburg, Otto-von-Guericke-Universität°, CIC 359, M Koenigsmann (1, 0/1) – Mainz, Johannes-Gutenberg-University°, CIC 786, K Kolbe (5, 4/1) – Marburg, Philipps Universitaet°, CIC 645, A Neubauer (6, 4/2) – Munchen, Kinderpoliklinik Universität*, CIC 513, M Fuehrer (219, 182/37) – Munchen, Klinikum Innenstad°, CIC 148 (1, 0/1) – Munchen, Kinderspital*, CIC 149, V Haunersches (37, 35/2) – Munchen, Klinikum der TU°, CIC 150, N Fischer (7, 2/5) – Munchen, Städt Krankenhaus°, CIC 664, M Hentrich (3, 0/3) – Munster, Klinik/Poliklinik für Kinderheilkunde*, CIC 505, H Jürgens (69, 34/35) – Munster, University of Münster°, CIC 680, J Kienast (1, 1/0) – Nurnberg, Klinikum Nürnberg°, CIC 625, H Wandt (4, 0/4) – Oldenburg, Klinikum°, CIC 749, B Metzner (11, 0/11) – Regensburg, University Regensburg°, CIC 787, E Holler (10, 5/5) – Rostock, Universität Rostock°, CIC 585, M Freund (7, 5/2) – Siegen, St Marienkrankenhaus*, CIC 135, T Gaska (1, 0/1) – Stuttgart, Katharinen Hospital°, CIC 143, J Schleicher (3, 0/3) – Stuttgart, Olgahospital*, CIC 701, E Koscielniak (71, 4/67) – Thienhaus, Klinikkinderhei*, CIC 639, F Berthold,(16, 0/16) – Tubingen, Universität Tübingen°, CIC 223, L Kanz (18, 18/0) – Tubingen, University Hospital*, CIC 535, R Handgretinger (362, 228/134) – Ulm, Abteilung Pädiatrie II Universitätskinderklinik*, CIC 204, W Friedrich (240, 230/10) – Wiesbaden, Deutsche Klinik°, CIC 311, R Schwerdtfeger (3, 2/1).

Greece:

Six teams, 268 (163/105)

Alexandroupolis, BMT Unit – Democritus University of Thrace°, CIC 681, G Bourika (1, 0/1) – Athens, Evangelismos Hospital°, CIC 622, N Harhalakis (31, 25/6) – Athens, BMT Unit°, CIC 643, G Karianakis (3, 1/2) – Athens, St Savvas Oncology Hospital°, CIC 751, A Efremidis (7, 0/7) – Athens; St Sophia Children's Hospital*, CIC 752, S Grafakos (173, 108/65) – Thessaloniki, Papanicolaou General Hospital°, CIC 561, A Fassas (53, 29/24).

Hungary:

Three teams, 181 (107/74)

Budapest, National Medical Centre°, CIC 504, A Poros (18, 18/0) – Budapest, St László Hospital#, CIC 739, T Masszi (92, 69/23) – Miskolc, Postgraduate Medical School*, CIC 599, K Nagy (71, 20/51).

India:

One team, 51 (51/0)

Vellore, Christian Medical College & Hospital°, CIC 312, M Chandy (51, 51/0).

Iran:

One team, 218 (191/27)

Teheran, Shariati Hospital#, CIC 633, A Ghavamzadeh (218, 191/27).

Ireland:

Two teams, 230 (186/44)

Dublin, St James Hospital°, CIC 257, S Mc Cann (66, 65/1) – Dublin, Our Lady's Hospital*, CIC 774, A O’Meara (164, 121/43).

Israel:

Five teams, 974 (663/311)

Haifa, Rambam Medical Center°, CIC 345, J Rowe (74, 38/36) – Jerusalem, Hadassah University Hospital*, CIC 258, S Slavin (526, 428/98) – Petach-Tikva, Schneider Children's Medical Center*, CIC 755, I Yaniv (263, 135/128) – Tel Aviv, Sourasky Medical Center°, CIC 161, E Naparstek (2, 2/0) – Tel Hashomer, Chaim Sheba Medical Center*, CIC 572, T Amos (109, 60/49).

Italy:

75 teams, 6226 (3563/2663)

Ancona, Az. Ospedale Umberto I°, CIC 788, P Leoni (25, 4/21) – Ancona, Clinica Pediatrica*, CIC 835. P Pierani (10 0/10) – Avellino, AORN San G Moscati° CIC 789, N Cantore (5, 0/5) – Avezzano, Ospedale Civile°, CIC 921, F Recchia (1, 0/1) – Bari, Università degli Studi°, CIC 649, V Liso (9, 1/8) – Bergamo, Ospedale°, CIC 658, A Rambaldi (22, 1/21) – Bologna, Clinica Pediatrica*, CIC 790, A Pession (277, 104/173) – Bologna, Istituto Seràgnoli°, CIC 240, G Bandini (46, 18/28) – Bolzano, Ospedale San Maurizio°, CIC 299, P Coser (10, 0/10) – Brescia, Clinica Pediatrica*, CIC 741, F Porta (222, 180/42) – Brescia, Spedali Civili°, CIC 288, G Rossi (10, 6/4) – Cagliari, Ospedale A Businco°, CIC 791, E Angelucci (7, 1/6) – Cagliari, II Clinica Pediatrica*, CIC 812, F Argiolu (69, 56/13) – Cagliari, PO ‘R Binaghi’#, CIC 811, G Lanasa (45, 44/1) – Catania, Clinica Pediatrica*, CIC 836, A Di Cataldo (24, 4/20) – Catania, Ospedale Ferrarotto°, CIC 792, G Milone (13, 3/10) – Cremona, Istituti Ospitalieri°, CIC 226, S Morandi (7, 1/6) – Ferrara, Ospedale S. Anna°, CIC 330, F Lanza (2, 0/2) – Firenze, Azienda Ospedaliera Meyer*, CIC 600, L Faulkner (76, 0/76) – Firenze, Ospedale di Careggi°, CIC 304, A Bosi (38, 25/13) – Genova, IRCCS G Gaslini*, CIC 274, G Dini (716, 222/494) – Genova, Ospedale S Martino°, CIC 217, A Bacigalupo (200, 160/40) – Latina, Ospdale S Maria Goretti°, CIC 379, A de Blasio (2, 1/1) – Messina, Università°, CIC 669, V Pitini (2, 0/2) – Milano, Ospedale Maggiore°, CIC 265, D Soligo (22, 6/16) – Milano, Ospedale Niguarda°, CIC 294, P Marenco (11, 4/7) – Milano, Istituto Europeo°, CIC 331, G Martinelli (2, 0/2) – Milano, Istituto Clinico Humanitas°, CIC 354, A Santoro (8, 1/7) – Milano, INT*, CIC 616, R Luksch (176, 0/176) – Milano, Istituto S. Raffaele°, CIC 813, M Bregni (1, 0/1) – Modena, Università Modena°, CIC 543, F Narni (6, 1/5) – Monza, Clinica Pediatrica*, CIC 279, C Uderzo (273, 222/51) – Monza, Ospedale S. Gerardo°, CIC 544, EM Pogliani (5, 0/5) – Napoli, Ospedale Cardarelli°, CIC 607, F Ferrara (3, 0/3) – Napoli, Università Federico°, CIC 766, B Rotoli (18, 13/5) – Napoli, Ospedale Pausillipon*, CIC 341, M Ripaldi (36, 15/21) – Napoli, Ospedale Cardarelli°, CIC 837, V Mettivier (1, 0/1) – Nuoro, Ospedale San Francesco°, CIC 793, A Gabbas (3, 0/3) – Padova, Clinica Pediatrica*, CIC 285, C Messina (318, 128/190) – Palermo, Ospedale V. Cervello°, CIC 392, R Scimè (44, 25/19) – Palermo, Università°, CIC 814, G Mariani (2, 0/2) – Parma, Università°, CIC 245, V Rizzoli (12, 0/12) – Pavia, IRCCS San Matteo*, CIC 557, F Locatelli (603, 430/173) – Pavia, IRCCS San Matteo, CIC 286, EP Alessandrino (19, 6/13) – Pavia, IRCCS San Matteo°, CIC 562, M Danova (1, 0/1) – Perugia, Ospedale Silvestrini*, CIC 815, A Amici (51, 16/35) – Perugia, Policlinico Monteluce°, CIC 573, M Liberati (6, 0/6) – Perugia, Policlinico Monteluce°, CIC 794, F Aversa (58, 47/11) – Pesaro, Ospedale Civile, CIC 529#, G Visani (1049, 1041/8) – Pescara, Ospedale Civile#, CIC 248, P Di Bartolomeo (219, 190/29) – Pisa, Clinica Pediatrica*, CIC 795, C Favre (91, 54/37) – Ravenna, Ospedale Civile°, CIC 306, G Rosti (35, 0/35) – Reggio Calabria, AO Bianchi-Melacrino-Morelli°, CIC 587, P Iacopino (42, 16/26) – Reggio Emilia, Arcispedale S. Maria Nuova°, CIC 660, L Gugliotta (1, 1/0) – Roma, Ospedale S. Camillo°, CIC 287, I Majolino (33, 13/20) – Roma, Università La Sapienza°, CIC 232, A Iori (386, 187/199) – Roma, Ospedale Bambino Gesú*, Ematologia CIC 315, M Caniglia (26, 15/11) – Roma, Ospedale Bambino Gesù*, Oncologia CIC 796, A Donfrancesco (109, 0/109) – Roma, Università Cattolica S. Cuore°, CIC 307, G Leone (5, 1/4) – Roma, Università Tor Vergata°, CIC 756, S Amadori (19, 16/3) – Roma, AOS Giovanni Addolorata°, CIC 948, M Persiani (1, 0/1) – San Giovanni Rotondo, Ospedale Casa Sollievo della Sofferenza*, CIC 350, M Pastore (40, 0/40) – San Giovanni Rotondo, Casa Sollievo della Sofferenza°, CIC 526, N Cascavilla (15, 2/13) – Siena, Policlinico Le Scotte°, CIC 321, G Marotta (1, 0/1) – Taranto, Ospedale Nord°, CIC 332, P Mazza (11, 4/7) – Torino, Ospedale Regina Margherita*, CIC 305, F Fagioli (363, 139/224) – Torino, AOS Giovanni°, CIC 231, M Falda (27, 7/20) – Torino, Universitaria°, CIC 696, M Boccadoro (3, 0/3) – Trieste, IRCCS Burlo Garofolo*, CIC 525, M Andolina (183, 116/67) – Udine, Università°, CIC 705, R Fanin (18, 5/13) – Venezia, Ospedale Civile SS Giovanni e Paolo°, CIC 502, T Chisesi (1, 0/1) – Verona, Ospedale Maggiore°, CIC 514, GL Cetto (1,0/1) – Verona, Policlinico GB Rossi°, CIC 623, F Benedetti (20, 7/13) – Verona, Policlinico GB Rossi*, CIC 834, R Balter (3, 0/3) – Vicenza, Ospedale S Bortolo°, CIC 797, F Rodeghiero (7, 4/3).

Lebanon:

One team, 4 (0/4)

Beirut, American University°, CIC 369, M Abboud (4, 0/4).

Netherlands:

Nine teams, 869 (732/137)

Amsterdam, Acad. Med. Centre*, CIC 247, H Vandenberg (38 2/36) – Amsterdam, Free University Hospital°, CIC 588, GJ Ossenkoppele (3, 1/2) – Amsterdam, The Netherlands Cancer Institute°, CIC 976, S Rodenhuis (1, 0/1) – Enschede, Medisch Spectrum Twente°, CIC 360, M Schaafsma (2, 0/2) – Leiden, University Hospital*, CIC 203, RM Egeler (595, 580/15) – Maastricht, University Hospital°, CIC 565, H Schouten (2, 1/1) – Nijmegen, University Medical Center St Radboud*, CIC 237, P Hoogerbrugge (93, 48/45) – Rotterdam, Erasmus MC-Daniel Center°, CIC 246, J Cornelissen (24, 13/11) – Utrecht, University Hospital*, CIC 239, M Bierings (111, 87/24).

New Zealand:

Two teams, 91 (42/49)

Christchurch, Department of Haematology°, CIC 798, N Patton (88, 40/48) – Wellington, Hospital°, CIC 581, K Romeril (3, 2/1).

Norway:

Two teams, 34 (18/16)

Oslo, Rikshospitalet*, CIC 235, L Brinch (18, 18/0) – Oslo, The Norwegian Radium Hospital°, CIC 782, S Kvaloy (16, 0/16).

Poland:

11 teams, 439 (289/150)

Gdansk, Medical University°, CIC 799, M Bienia (5, 3/2) – Katowice, Silesian Medical Academy°, CIC 677, J Holowiecki (85, 39/46) – Krakow, Jagiellonian University°, CIC 553, A Skotnicki (2, 2/0) – Lublin, Children's University Hospital*, CIC 678, JR Kowalczyk (70, 24/46) – Poznan, University of Medical Sciences*, CIC 641 J Wachowiak (124, 117/7) – Poznan, K. Marcinkowski University°, CIC 730, M Komarnicki (38, 13/25) – Warsaw, Curie-Memorial Institute°, CIC 800, J Walewski (2, 2/0) – Warsaw, Military Medical Academy°, CIC 816, P Rzepecki (6, 5/1) – Warsaw, Central Clinical Hospital°, CIC 954, W Wiktor-Jedrzejczak (3, 2/1) – Wroclaw, Lower Silesian Centre#, CIC 538, A Lange (94, 80/14) – Wroclaw, Medical University*, CIC 817, A Chybicka (10, 2/8).

Portugal:

Two teams, 147 (89/58)

Lisboa, Inst. Portugues Oncologia#, CIC 300, M Abecasis (100, 70/30) – Porto, Inst. Portugues Oncologia°, CIC 291, P Pimentel (47, 19/28).

Romania:

Two teams, 4 (1/3)

Bucharest, Fundeni University Institute°, CIC 296, C Arion (1, 1/0) – University of Medicine*, CIC 174, M Serban (3, 0/3).

Russia:

Four teams, 87 (30/57)

Novosibirsk, Institute of Clinical Immunology#, CIC 376, IA Lisukov (8, 0/8) – St Petersburg, Clinical Center for Advanced Medical Technologies°, CIC 370, E Podoltseva (1, 0/1) – St Petersburg, Institute of Hematology°, CIC 724, KM Abdulkadirov (15, 6/9) – St Petersburg, Pavlov Medical University#, CIC 725, BV Afanassiev (63, 24/39).

Saudi Arabia:

Two teams, 210 (183/27)

Riyadh, King Faisal Specialist Hospital°, CIC 397, M Ayas (189, 162/27) – Riyadh, Armed Forces Hospital#, CIC 818, A Alabdulaaly (21, 21/0).

Serbia and Montenegro:

One team, 25 (22/3)

Belgrado, Military Medical Academy°, CIC 582, M Malesevic (25, 22/3).

Slovakia:

Three teams, 56 (26/30)

Banskà Bystrica, Roosevelt Hospital°, CIC 333, I Markuljak (2, 0/2); Bratislava, University Hospital°, CIC 610, M Mistrik (7, 4/3); Bratislava, Pediatric University Hospital*, CIC 684, J Lukac (47, 22/25).

Slovenia:

One team, 21 (13/8)

Ljubljana, University Med. Center°, CIC 640, J Pretnar (21, 13/8).

South Africa:

Two teams, 107 (79/28)

Cape Town, UCT Medical School°, CIC 512, N Novitzky (43, 34/9) – Cape Town, Constantiaberg Medi-Clinic°, CIC 772, P Jacobs (64, 45/19).

Spain:

35 teams, 2420 (1012/1408)

Barakaldo, Hospital de Cruces°, CIC 393, JC Garcia (1, 0/1) – Barcelona, Hospital Clinic°, CIC 214, E Carreras (138, 96/42) – Barcelona, Hospital Santa Creu i Sant Pau*, CIC 260, I Badell-Serra (329, 131/198) – Barcelona, Hospital M. Infantil Vall d’Hebron*, CIC 527, J Ortega (503, 228/275) – Barcelona, Hospital Universitari Germans Trias i Pujol°, CIC 613, JM Ribera (3, 0/3) – Barcelona, Hospital Sant Joan de Deu*, CIC 668, J Estella (47, 1/46) – Barcelona, Clinica Corachan°, CIC 758 (4, 0/4) – Barcelona, Hospital Universitari de Bellvitge°, CIC 759, A Fernández de Sevilla Ribosa (20, 10/10) – Cadiz, Hospital Universitario Puerta del Mar°, CIC 679, JA Munoz (4, 0/4) – Cadiz Jerez de la Frontera, Hospital del SAS°, CIC 612, A Leon (17, 2/15) – Hospital Reina Sofia°, CIC 238, A Torres Gomez (88, 66/22) – Granada, Hospital Univ. Virgen de las Nieves°, CIC 559, J de Pablos (4, 1/3) – La Coruna, Hospital Juan Canalejo°, CIC 361, JP Torres (1, 0/1) – Las Palmas de Gran Canaria, Hospital Insular°, CIC 335, JD González San Miguel (1, 0/1) – Las Palmas de Gran Canaria, Hospital Dr Negrin#, CIC 537, S Jiminez (12, 3/9) – Lugo, Hospital Xeral-Calde°, CIC 371 (1, 0/1) – Madrid, Hospital de la Princesa°, CIC 236 JM Fernández-Ranada (17, 8/9) – Madrid, Clinica Puerta de Hierro°, CIC 728, M Fernandez (31, 19/12) – Madrid, Niño Jesus Children's Hospital*, CIC 732, M Diaz (318, 102/216) – Madrid, Hospital Infantil La Paz*, CIC 734, AM Martínez-Rubio (203, 72/131) – Madrid, Hospital Gregorio Marañón°, CIC 819, A Cantalejo (19, 8/11) – Malaga, Hospital Carlos Haya°, CIC 576, ME González Valentín (7, 4/3) – Murcia, Hospital Morales Meseguer°, CIC 735, J Moraleda Jimenez (17, 7/10) – Oviedo, Hospital Covadonga°, CIC 642, D Carrera Fernández (22, 4/18) – Palma de Mallorca, Hospital Universitario Son Dureta°, CIC 722, J Besalduch (23, 5/18) – Pamplona, Hospital de Navarra°, CIC 577, E Perez Equiza(7, 0/7) – Pamplona, Clínica Universitaria de Navarra°, CIC 737, J Rifon (20, 6/14) – Salamanca, Hospital Clínico°, CIC 727, D Caballero (26, 12/14) – San Sebastian, Hospital Aranzazu°, CIC 598, J Marin Gonzales (18, 9/9) – Santander, Hospital U. Marqués de Valdecilla°, CIC 242, A Iriondo Atienza (161, 102/59) – Sevilla, Hospital Virgen del Rocio#, CIC 769, J Rodriguez Fernandez (138, 46/92) – Valencia, Hospital Clínico Universitario°, CIC 282, J García-Conde (5, 0/5) – Valencia, Hospital Infantil La Fe*, CIC 653, V Castel (173, 42/131) – Valencia, Hospital Universitario La Fe*, CIC 663, M Sanz (40, 28/12) – Zaragoza, Hospital Clínico°, CIC 531, M Gutierrez Martin (2, 0/2).

Sweden:

Eight teams, 822 (555/267)

Goeteborg, Queen Silvia Children's Hospital*, CIC 289, A Fasth (181, 112/69) – Huddinge, University Hospital*, CIC 212, P Ljungman (362, 324/38) – Linkoping, University Hospital°, CIC 740, N Theorin (12, 2/10) – Lund, University Hospital*, CIC 283, A Bekassy (101, 43/58) – Orebro, University Hospital°, CIC 738, U Tidefelt (1, 0/1) – Stockolm, Karolinska Hospital°, CIC 626, M Björkholm (14, 0/14); Umea, University Hospital°, CIC 731, A Wahlin (11, 2/9) – Uppsala, University Children's Hospital*, CIC 266, J Arvidson (140, 72/68).

Switzerland:

Nine teams, 461 (299/162)

Basel, Kantonsspital°, CIC 202, A Gratwohl (200, 167/33) – Bellinzona, Istituto Oncologico della Svizzera Italiana°, CIC 829, L Leoncini-Franscini (1, 0/1) – Bern, University Hospital°, CIC 221, K Leibundgut (44, 0/44) – Geneva, Hopital Cantonal Universitarie*, CIC 261, P Wacker (52, 36/16) – Lausanne, Universitaire Vaudois*, CIC 820, M Nenadov-Beck (18, 0/18) – St Gallen, Kantonsspital St Gallen°, CIC 324, U Hess (6, 0/6) – Zurich,University Hospital°, CIC 208, U Schanz (26,13/13) – Zurich, University Children's Hospital*, CIC 334, R Seger (112, 81/31) – Zurich, Klinik Im Park°, CIC 700, V Hofmann (2, 2/0).

Turkey:

14 teams, 228 (153/75)

Ankara, Hacettepe University°, CIC 292, E Kansu (9, 8/1) – Ankara, Gülhane Military Medical Academy°, CIC 372, F Arpaci (17, 8/9) – Ankara, University Medical School°, CIC 617, G Gurman (47, 38/9) – Ankara, Numune Education and Research Hospital°, CIC 691, M Ayli (14, 7/7) – Antalya, Akdeniz University Medical School*, CIC 618, MA Yesilipek (40,30/10) – Aydin, Adnan Menderes University°, CIC 187, Z Bolaman (2, 1/1) – Bornova-Izmir, Ege Universitesi Typ Fakultesi*, CIC 621, S Kansoy (22, 12/10) – Bornova-Izmir, Ege Univ. Medical School Dept. of Hematology°, CIC 628, S Cagirgan (5, 0/5) – Istanbul, Marmara University°, CIC 714, M Cetiner (12, 8/4) – Istanbul, Tip Fakueltesi°, CIC 760, S Kalayoglu-Besisik (7, 5/2) – Istanbul, Cerrahpasa Medical School°, CIC 761, B Ferhan (14, 11/3) – Istanbul, Our Children Leukemia Foundation*, CIC 762, G Gedikoglu (33, 24/9) – Kayseri, Erciyes University°, CIC 627, A Unal (4, 0/4) – Trabzon, Karadeniz Technical University°, CIC 170, E Ovali (2, 1/1).

United Kingdom:

42 teams, 4202 (2904/1298)

Aberdeen, Grampian University Hospital°, CIC 344, D Culligan (2, 0/2) – Bangor, Gwynedd Hospital°, CIC 736, J Seale (1, 0/1) – Belfast, City Hospital°, CIC 268, F Jones (9, 4/5); Birmingham, Heartlands Hospital°, CIC 284, DW Milligan (13, 2/11) – Birmingham, Queen Elizabeth Medical Centre°, CIC 387, C Craddock (20, 9/11) – Birmingham, Children's Hospital*, CIC 781, P Darbyshire (329, 267/62) – Bournemouth, Royal Bournemouth Hospital°, CIC 765, S Killick (2, 1/1) – Bristol, Royal Hospital for Children*, CIC 386, J Cornish (673, 581/92) – Cambridge, Addenbrookes Hospital°, CIC 566, C Crawley (63, 6/57) – Cardiff, University of Wales°, CIC 303, AK Burnett (7, 7/0) – Cardiff, Llandough Hospital°, CIC 776, A Webb (26, 8/18) – Clydebank, HCI International Medical Centre°, CIC 317, B Harper (6, 4/2) – Edinburgh, Western General Hospital°, CIC 228, J Davies (17, 13/4) – Edinburgh, Royal Hospital for Sick Children*, CIC 706 (18, 0/18) – Exeter, Royal Deevon and Exeter Hospital°, CIC 571, M Joyner (1, 0/1) – Glasgow, Royal Infirmary°, CIC 244, G McQuaker (40, 25/15) – Glasgow, The Western Infirmary°, CIC 325, T Fitzsimons (2, 0/2) – Glasgow, Royal Hospital for Sick Children*, CIC 707, B Gibson (117, 87/30) – Leeds, St James’ University Hospital°, CIC 254, G Cook (194, 109/85) – Leicester, Royal Infirmary°, CIC 713, A Hunter (22, 6/16) – Liverpool, Royal University Hospital°, CIC 501, RE Clark (18, 16/2) – Liverpool, Royal Children's NHS Trust*, CIC 773, M Caswell (71, 41/30) – London, Hammersmith Hospital°, CIC 205, J Apperley (282, 272/10) – London, Royal Free Hospital#, CIC 216, S Mackinnon (239, 198/41) – London Surrey, Royal Marsden Hospital°, CIC 218, M Potter (328, 162/166) – London, Univ. College London Hospital°, CIC 224, A Goldstone (108, 36/72) – London, Great Ormond Street Hospital*, CIC 243, P Veys (521, 348/173) – London, The London Clinic°, CIC 263, M Potter (27, 8/19) – London, St George's Hospital°, CIC 539, J Marsh (47, 47/0) – London, Guy's Hospital°, CIC 721, M Kazmi (4, 0/4) – London, GKT School of Medicine°, CIC 763, G Mufti (4, 3/1), London, St Bartholomew's and The Royal Hospital°, CIC 768, J Gribben (77, 40/37) – Manchester, Royal Children's Hospital*, CIC 521, RF Wynn (392, 274/118) – Manchester, Christie NHS Trust Hospital°, CIC 780, E Liakopoulou (28, 6/22) – Manchester, Royal Infirmary°, CIC 601, J Liu Yin (5, 3/2) – Newcastle upon Tyne, Royal Victoria infirmary*, CIC 276, GH Jackson (252, 203/49) – Norwich, The Norfolk and Norwich University Hospital°, CIC 391, J Parker (1, 0/1) – Nottingham, City Hospital°, CIC 717, NH Russell (18, 10/8) – Oxford, Radcliffe Hospital*, CIC 255, T Littlewood (47, 11/36) – Sheffield, Children's Hospital*, CIC 778, A Vora (116, 79/37) – Southampton, General Hospital°, CIC 704, K Orchard (54, 18/36) – Stoke on Trent, North Staffordshire Hospital°, CIC 394, R Chasty (1, 0/1).

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Miano, M., Labopin, M., Hartmann, O. et al. Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 39, 89–99 (2007). https://doi.org/10.1038/sj.bmt.1705550

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  • DOI: https://doi.org/10.1038/sj.bmt.1705550

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