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Idiopathic thrombocytopenic purpura after influenza vaccination in a bone marrow transplantation recipient

Bone Marrow Transplantation volume 38, pages 323–324 (2006)Cite this article

The benefit of influenza vaccination after bone marrow transplantation (BMT) was reported in a recent issue of Bone Marrow Transplantation by Machado et al.1 The authors showed that influenza vaccination played an important role in protecting BMT recipients against influenza in the analysis of a cohort of 177 BMT recipients. With regard to this issue, we present here a case of a BMT recipient who developed idiopathic thrombocytopenic purpura (ITP) after receiving influenza vaccination.

A 19-year-old Japanese woman with Philadelphia chromosome-positive acute lymphoblastic leukaemia was transferred to our hospital to receive allogeneic BMT. Although the patient was in second complete remission (CR), allogeneic BMT was considered because of the poor prognosis of the disease. As she did not have a related or unrelated HLA-matched donor, her HLA-haploidentical brother was chosen as a donor for allogeneic BMT.2 The HLA profiles of the patient and donor were as follows: patient A2 B61 Cw8 DRB1*0401/A26 B62 Cw9 DRB1*1406, and donor A2 B61 Cw8 DRB1*0401/A33 B44 Cw- DRB1*0803. The protocol was approved by the institutional review board of Osaka University, and written informed consent was obtained from the patient.

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Acknowledgements

The authors thank Professor Yuzuru Kanakura (Osaka University Graduate School of Medicine, Japan) for suggestions and support. The authors also thank Machiko Oshida for technical assistance.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan

    K Ikegame

  2. Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

    K Kaida, T Fujioka, H Hasei, T Inoue, Y Taniguchi, S Yoshihara & H Ogawa

  3. Department of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan

    M Kawakami

  4. Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan

    S Hayashi & Y Kurata

  5. Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

    H Ogawa

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  1. K Ikegame
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  2. K Kaida
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  3. T Fujioka
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  11. H Ogawa
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Correspondence to H Ogawa.

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Ikegame, K., Kaida, K., Fujioka, T. et al. Idiopathic thrombocytopenic purpura after influenza vaccination in a bone marrow transplantation recipient. Bone Marrow Transplant 38, 323–324 (2006). https://doi.org/10.1038/sj.bmt.1705442

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