Abstract
Cord blood transplantation (CBT) is a promising alternative means of allogeneic stem cell transplantation. However, limited cell doses may compromise outcome. To enhance engraftment, CBT has been conducted using two units with promising results. However, little is known about the mechanism of engraftment. Here, we analyzed the early engraftment kinetics of eight patients given two unit umbilical CBT. Early engraftment kinetics revealed dominancy of one of two units from the day of engraftment (absolute neutrophil count >0.5 × 109/l). The median value of percentage of the predominant unit by chimerism analysis at the time of engraftment was 88% (60–100%). Two units CBT was found to be a safe, effective and promising alternative treatment option with good engraftment potential. Dominancy occurred early after CBT and is probably influenced by multiple factors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 321: 1174–1178.
Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100: 1611–1618.
Barker JN, Wagner JE . Umbilical-cord blood transplantation for the treatment of cancer. Nat Rev Cancer 2003; 3: 526–532.
Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343–1347.
Kang HJ, Shin HY, Choi HS, Ahn HS . Fludarabine, cyclophosphamide plus thymoglobulin conditioning regimen for unrelated bone marrow transplantation in severe aplastic anemia. Bone Marrow Transplant 2004; 34: 939–943.
Verneris MR, Claudio B, DeFor TE, Barker J, Weisdorf DJ, Blazar BR et al. Risk of relapse (REL) after umbilical cord blood transplantation (UCBT) in patients with acute leukemia: marked reduction in recipients of two units. Blood 2005; 106: 93a.
De Lima M, St John LS, Wieder ED, Lee MS, McMannis J, Karandish S et al. Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br J Haematol 2002; 119: 773–776.
Gluckman E, Rocha V, Arcese W, Michel G, Sanz G, Chan KW et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 2004; 32: 397–407.
Acknowledgements
This study was supported by Grant No. 04-2005-054 from SNUH Research Fund and by grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050089).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kang, H., Kho, S., Jang, M. et al. Early engraftment kinetics of two units cord blood transplantation. Bone Marrow Transplant 38, 197–201 (2006). https://doi.org/10.1038/sj.bmt.1705423
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1705423
Keywords
This article is cited by
-
Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT
Blood Cancer Journal (2014)
-
Peri-engraftment syndrome in allogeneic hematopoietic SCT
Bone Marrow Transplantation (2013)
-
Retroviral Gene Therapy for X-linked Chronic Granulomatous Disease: Results From Phase I/II Trial
Molecular Therapy (2011)
-
Quantitative monitoring of multi-donor chimerism: a systematic, validated framework for routine analysis
Bone Marrow Transplantation (2010)
-
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
Nature Medicine (2010)