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Post-Transplant Events

Long-term renal function after hemopoietic stem cell transplantation in children

Bone Marrow Transplantation volume 36, pages 605–610 (2005)Cite this article

Summary:

Glomerular function of all long-term survivors who underwent hemopoietic stem cell transplantation (HSCT) from 1991 to 1998 (study I, n=121) was studied retrospectively. In addition, we prospectively analyzed glomerular and tubular function of all long-term surviving children who received an HSCT between 1998 and 2000 (study II, n=41). We found a lower prevalence of children with chronic renal failure (CRF) post-HSCT in our more recent cohort (study II: 10%) as compared to the older cohort (study I: 24%) 5.0 (0.7 s.d.) and 7.6 (2.4 s.d.) year's post-HSCT, respectively. Furthermore, it seems that renal function may stabilize after 1-year post-HSCT. None of the patients required dialysis or antihypertensive medication at long-term follow-up. The sole predictor of CRF in our study was high serum creatinine pre-HSCT (P=0.007), while acute renal failure within 3 months after HSCT (P=0.08) only showed a trend towards predicting CRF. We could not confirm a relation of conditioning with irradiation with CRF post-HSCT, as was shown in several other pediatric and adult studies. Proximal and distal tubular dysfunction only occurred in a minority of long-time survivors of HSCT (3–12 and 9–13%, respectively) and had no clinical consequences.

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Authors and Affiliations

  1. Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

    J E Kist-van Holthe, D Bresters, Y M Ahmed-Ousenkova, C A Goedvolk, F C H Abbink & R G M Bredius

  2. Department of Medical Statistics, Rijksuniversiteit Leiden, Leiden, The Netherlands

    R Wolterbeek

  3. Department of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands

    E K J Pauwels

  4. Department of Pediatrics, Erasmus MC-Sophia Kinderziekenhuis, Rotterdam, The Netherlands

    A J van der Heijden

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  1. J E Kist-van Holthe
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  2. D Bresters
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  3. Y M Ahmed-Ousenkova
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  4. C A Goedvolk
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  9. A J van der Heijden
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Correspondence to J E Kist-van Holthe.

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Kist-van Holthe, J., Bresters, D., Ahmed-Ousenkova, Y. et al. Long-term renal function after hemopoietic stem cell transplantation in children. Bone Marrow Transplant 36, 605–610 (2005). https://doi.org/10.1038/sj.bmt.1705110

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