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Features of the metabolic syndrome present in survivors of bone marrow transplantation in adulthood

Bone Marrow Transplantation volume 36, pages 279–280 (2005)Cite this article

Chatterjee et al1 report five female adult recipients of bone marrow transplantation (BMT) presenting with core signs of metabolic syndrome. They state that no data are available on metabolic syndrome in adult BMT recipients for haematological malignancy. In March 2004, we reported the incidence of features of the metabolic syndrome in a group of 16 adult recipients of BMT.2

The clustering of hyperinsulinaemia, impaired glucose intolerance, dyslipidaemia, hypertension and obesity is characteristic of the metabolic syndrome. There are two main classifications of the metabolic syndrome, the World Health Organization (WHO)3 and the National Cholesterol Education Program and Treatment of High Blood Cholesterol in Adults Panel (NCEP/ATPIII).4 The WHO definition requires evidence of insulin resistance and therefore an oral glucose tolerance test; however, the NCEP ATP III definition is more pragmatic and developed to be used in clinical practice. Both of these classifications predict type II diabetes, cardiovascular disease and cardiovascular mortality.5, 6

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References

  1. Chatterjee R, Palla K, McGarrigle HH et al. Syndrome ‘X’ in adult female recipients of bone marrow transplantation for haematological malignancies. Bone Marrow Transplant 2005; 35: 209–210.

    Article  CAS  Google Scholar 

  2. Higgins K, Noon C, Cartwright V et al. Features of the metabolic syndrome present in survivors of bone marrow transplantation in adulthood. Bone Marrow Transplant 2004; 33 (Suppl 1): S216–S217.

    Google Scholar 

  3. WHO consultation. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. WHO: Geneva, 1999.

  4. National Institutes of Health. Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Institutes of Health: Bethesda, MD, 2001. NIH Publication 01-3670.

  5. Sattar N, Gaw A, Scherbakova O et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003; 108: 414–419.

    Article  CAS  Google Scholar 

  6. Malik S, Wong ND, Franklin SS et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004; 110: 1245–1250.

    Article  Google Scholar 

  7. Amin P, Shah S, Walker D et al. Adverse metabolic and cardiovascular risk following treatment of acute lymphoblastic leukaemia in childhood; two case reports and a literature review. Diabet Med 2001; 18: 849–853.

    Article  CAS  Google Scholar 

  8. Gaede P, Vedel P, Larsen N et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Eng J Med 2003; 348: 383–393.

    Article  Google Scholar 

  9. Tuomilehto J, Lindstrom J, Eriksson JG et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Eng J Med 2001; 344: 1343–1350.

    Article  CAS  Google Scholar 

  10. Esposito K, Marfella R, Ciotola M et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome. A randomized trial. JAMA 2004; 292: 1440–1446.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, UK

    K Higgins, M Davies & T Howlett

  2. Bone Marrow Transplantation Unit, Dept of Haematology, Leicester Royal Infirmary, Leicester, UK

    C Noon & A Hunter

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  1. K Higgins
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  2. C Noon
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  3. M Davies
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  4. T Howlett
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  5. A Hunter
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Higgins, K., Noon, C., Davies, M. et al. Features of the metabolic syndrome present in survivors of bone marrow transplantation in adulthood. Bone Marrow Transplant 36, 279–280 (2005). https://doi.org/10.1038/sj.bmt.1705060

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