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Sequential reduced- and full-intensity allografting using same donor in a child with chronic granulomatous disease and coexistent, significant comorbidity

Bone Marrow Transplantation volume 34, pages 1009–1010 (2004)Cite this article

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens. This leads to a predisposition to recurrent and potentially life-threatening bacterial and fungal infections and, occasionally, a variety of intestinal manifestations, from granulomata and obstruction, through to an inflammatory bowel-like syndrome.1 We report the management of a boy with a life-threatening episode of toxic megacolon and associated fistula.

This boy, with a family history of CGD, was diagnosed as having the condition by the nitro blue tetrazolium (NBT) test. Along with recurrent infections, he developed inflammatory bowel disease in association with his CGD requiring frequent hospitalization and maintenance prednisolone to control symptoms. He had severe growth retardation resistant to growth hormone.

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Authors and Affiliations

  1. Department of Haematology, Royal Oldham Hospital, Rochdale Road, Oldham, UK

    J A T Nicholson

  2. Department of Paediatric Haematology, Royal Manchester Children's Hospital, Manchester, UK

    R F Wynn, T F Carr & A M Will

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  1. J A T Nicholson
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  2. R F Wynn
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  3. T F Carr
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  4. A M Will
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Nicholson, J., Wynn, R., Carr, T. et al. Sequential reduced- and full-intensity allografting using same donor in a child with chronic granulomatous disease and coexistent, significant comorbidity. Bone Marrow Transplant 34, 1009–1010 (2004). https://doi.org/10.1038/sj.bmt.1704729

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