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Nonmyeloablative stem cell transplantation following a cytoreductive autograft in patients with non-Hodgkin's lymphoma who relapse after autologous transplantation

Bone Marrow Transplantation volume 34, pages 915–916 (2004)Cite this article

Autologous stem cell transplantation (SCT) is commonly used in relapsing non-Hodgkin's lymphoma (NHL) patients with chemosensitivity to a salvage regimen. However, many such patients fail to achieve long-term survival because recurrence is due either to the inability to eliminate tumor cells in the patient or from malignant cells contaminating the infused graft.1, 2 The clinical course of NHL patients with progressive disease after autologous SCT is devastating. In these patients, allogeneic SCT has the advantage of a graft-versus-lymphoma (GVL) effect, a higher frequency of remission, and lower risk of relapse, as compared with autologous SCT. Unfortunately, the high transplantation-related mortality (TRM) of up to 40% and the adverse effects of graft-versus-host disease (GVHD) reduce these benefits.3, 4 Nonmyeloablative SCT (NST) for NHL patients who relapse after autologous SCT is not yet satisfactory.5 Recently, autologous SCT followed by NST has emerged as an innovative approach to treat high-risk NHL in patients previously heavily treated or those with primary refractory disease. This treatment appears effective and has a low TRM.6

We report two cases of NHL who were successfully treated with autografting, followed by NST as a salvage treatment for relapsed NHL after previous autologous SCT.

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Acknowledgements

This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (01-PJ10-PG6-01GN16-0005).

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Authors and Affiliations

  1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea

    D-H Yang, J-J Lee, Y-K Kim, S-H Cho, I-J Chung & H-J Kim

  2. Genome Research Center for Hematopoietic Diseases, Chonnam National University HwaSun Hospital, Jeonnam, South Korea

    D-H Yang, J-J Lee, Y-K Kim, S-H Cho, I-J Chung & H-J Kim

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  1. D-H Yang
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Yang, DH., Lee, JJ., Kim, YK. et al. Nonmyeloablative stem cell transplantation following a cytoreductive autograft in patients with non-Hodgkin's lymphoma who relapse after autologous transplantation. Bone Marrow Transplant 34, 915–916 (2004). https://doi.org/10.1038/sj.bmt.1704668

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