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Conditioning Regimens

High-dose cytosine arabinoside and etoposide with total body irradiation as a preparatory regimen for allogeneic hematopoietic stem-cell transplantation in patients with acute lymphoblastic leukemia

Bone Marrow Transplantation volume 34, pages 299–303 (2004)Cite this article

Summary:

One approach to improving the outcome of allogeneic hematopoietic stem-cell transplantation for acute lymphoblastic leukemia (ALL) is to intensify the pretransplant conditioning regimen without increasing toxicity. We used an intensified conditioning regimen consisting of high-dose cytosine arabinoside (3 g/m2 twice daily i.v. for 3 consecutive days, total six doses), high-dose etoposide (1 g/m2 once daily i.v. during the first 2 days) and total body irradiation (TBI) (HDACE-TBI) in ALL patients. We retrospectively analyzed 21 patients treated with HDACE-TBI, of whom 18 were in complete remission (CR) and three were in non-CR at transplantation. Although gastrointestinal toxicities were common, critical regimen-related toxicities were not seen in any patients. One patient demonstrated veno-occlusive disease, which could be controlled conservatively. The disease-free survival rate of 18 patients in CR at transplantation was 61%. These results demonstrate that the HDACE-TBI combination regimen is a feasible alternative to other preparatory regimens and does not increase the regimen-related toxicity.

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Authors and Affiliations

  1. Division of Hematology, Niigata University Graduate School of Medical and Dental Sciences, Japan

    N Sato, T Kuroha, M Masuko, H Takahashi, T Yano, T Abe & Y Aizawa

  2. Division of Bone Marrow Transplantation, Niigata University Medical Hospital, Niigata, Japan

    T Furukawa & S Hashimoto

  3. Division of Blood Transfusion, Niigata University Medical Hospital, Niigata, Japan

    I Fuse

  4. Nagaoka Red Cross Hospital, Niigata, Japan

    T Koike

  5. Department of Medicine, Division of Hematology and Rheumatology, Tokai University School of Medicine, Kanagawa, Japan

    K Kishi

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  1. N Sato
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  2. T Furukawa
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  10. T Koike
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Correspondence to T Furukawa.

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Sato, N., Furukawa, T., Kuroha, T. et al. High-dose cytosine arabinoside and etoposide with total body irradiation as a preparatory regimen for allogeneic hematopoietic stem-cell transplantation in patients with acute lymphoblastic leukemia. Bone Marrow Transplant 34, 299–303 (2004). https://doi.org/10.1038/sj.bmt.1704575

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