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Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease

Bone Marrow Transplantation volume 33, pages 1257–1259 (2004)Cite this article

Summary:

A 12-year-old girl presented with arthritis, myalgia, anemia and positive ANA. Subsequently, she developed recurrent episodes of pulmonary hemorrhage, thrombocytopenia, CNS abnormalities, skin ulcers and diffuse calcinosis. This was followed by secondary antiphospholipid syndrome. Despite vigorous immunosuppression, the patient became bedridden. A peripheral blood stem cell autograft was offered when she developed pulmonary hypertension and digital ischemia at the age of 16 years. The post-transplantation course was uneventful. Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules.

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Acknowledgements

The authors thank Mrs M Perlmutter for her help in the preparation of this paper.

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Authors and Affiliations

  1. Department of Pediatric Hemato-Oncology, Meyer Children's Hospital, Haifa, Israel

    R Elhasid & M Ben-Arush

  2. Department of Hematology and Bone Marrow Transplantation, Haifa, Israel

    J M Rowe

  3. Department of Pediatrics and Pediatric Rheumatology Unit, Meyer Children's Hospital, Haifa, Israel

    D Berkowitz & R Brik

  4. Department of Nuclear Medicine, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    R Bar-Shalom

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  1. R Elhasid
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  2. J M Rowe
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  3. D Berkowitz
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  4. M Ben-Arush
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  5. R Bar-Shalom
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  6. R Brik
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Correspondence to R Elhasid.

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Elhasid, R., Rowe, J., Berkowitz, D. et al. Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease. Bone Marrow Transplant 33, 1257–1259 (2004). https://doi.org/10.1038/sj.bmt.1704514

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  • DOI: https://doi.org/10.1038/sj.bmt.1704514

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