Summary:
Second malignancies are uncommon events in the survivors of allogeneic transplant procedures, although they are increased compared to normal control populations. Among these malignancies, sarcomas are exceedingly rare. In addition, relapse of primary myelodysplasia rarely occurs after 5 years from the time of allogeneic transplantation. This report describes an unusual presentation of liposarcoma with concomitant relapse of underlying myelodysplasia developing in a patient 9 years after the first of two allogeneic transplantations.
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References
Curtis RE, Rowlings PA, Deeg HJ et al. Solid cancers after bone marrow transplantation. N Engl J Med 1997; 336: 897–904.
Socie G, Stone JV, Wingard JR et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. N Engl J Med 1999; 341: 14–21.
Kolb HJ, Socie G, Duell T et al. Malignant neoplasms in long-term survivors of bone marrow transplantation. Ann Intern Med 1999; 131: 738–744.
Witherspoon RP, Fisher LD, Schoch G et al. Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia. N Engl J Med 1989; 321: 784–789.
Benesch M, Deeg HJ . Hematopoietic cell transplantation for adult patients with myelodysplastic syndromes and myeloproliferative disorders. Mayo Clinic Proc. 2003; 78: 981–990.
Coindre JM, Terrier P, Guillou L et al. Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer 2001; 91: 1914–1926.
Stoeckle E, Coindre JM, Bonvalot S et al. Prognostic factors in retroperitoneal sarcoma: a multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group. Cancer 2001; 92: 359–368.
Brincker H, Christensen BE, Cold S . Two pregnancy-associated late relapses in acute lymphoblastic leukemia. Haematologica 1989; 74: 289–291.
Antunez de Mayolo J, Ahn YS, Temple JD et al. Spontaneous remission of acute leukemia after the termination of pregnancy. Cancer 1989; 63: 1621–1623.
Franchi A, Arganini L, Baroni G et al. Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. J Pathol 1998; 185: 284–289.
Kloen P, Gebhardt MC, Perez-Atayde A et al. Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta 3 is related to disease progression. Cancer 1997; 80: 2230–2239.
Bouche M, Canipari R, Melchionna R et al. TGF-β autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells. FASEB J 2000; 14: 1147–1158.
Blobe GC, Schiemann WP, Lodish HF . Role of transforming growth factor β in human disease. N Engl J Med 2000; 342: 1350–1358.
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Walker, L., Gatter, K., Sekhon, H. et al. Late relapse of myelodysplasia after allogeneic transplantation concomitant with new presentation of invasive liposarcoma as a secondary neoplasm. Bone Marrow Transplant 33, 1215–1218 (2004). https://doi.org/10.1038/sj.bmt.1704507
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DOI: https://doi.org/10.1038/sj.bmt.1704507