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Mobilization

A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients

Bone Marrow Transplantation volume 33, pages 499–502 (2004)Cite this article

Summary:

Extensive prior treatment with cytotoxic agents is associated with impaired mobilization of hematopoietic cells. To assess the effect of a single course of standard-dose chemotherapy (CT), we compared the results of filgrastim-induced mobilization among two sequential groups of grade III–IV malignant glioma patients included in a hematopoietic transplantation program. The first group (21 patients) had never been treated with CT until 2 days after surgery, when they received a course of 100 mg/m2 BCNU (IV) and 100 mg intracarotid cisplatin for cytoreduction (not for mobilization). At 1 month after this CT, they were mobilized with 12 μg/kg filgrastim. The second group (22 patients) was mobilized with the same dose of filgrastim directly after the surgery, without having ever received any prior CT. The blood level of CD34+ cells was significantly lower in the CT-treated patients, both on the fourth day of filgrastim (15 vs 36 cells × 106/l; P=0.01) and on the fifth (25 vs 58 cells × 106/l; P=0.003), as it was the number of CD34+ cells collected per apheresis (1.3 vs 3.5 × 106/l; P<0.0005). The toxic effect of a single course of BCNU-cisplatin CT led to significant impairment of the filgrastim-induced mobilization response.

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References

  1. Del Cañizo MC, López N, Vázquez L et al . Hematopoietic damage prior to PBSCT and its influence on hematopoietic recovery. Haematologica 1999; 84: 511–516.

    PubMed  Google Scholar 

  2. Trainor KJ, Morley AA . Screening of cytotoxic drugs for residual bone marrow damage. J Natl Cancer Inst 1976; 57: 1237–1239.

    Article  CAS  Google Scholar 

  3. Tricot G, Jagannath S, Vesole D et al. Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients. Blood 1995; 85: 588–596.

    CAS  Google Scholar 

  4. Haas R, Möhle R, Frühauf S et al. Patient characteristics associated with successful mobilizing and autografting of peripheral bold progenitor cells in malignant lymphoma. Blood 1994; 83: 3787–3794.

    CAS  Google Scholar 

  5. Bensinger W, Appelbaum F, Rowley S et al. Factors that influence collection and engraftment of autologous peripheral blood stem cells. J Clin Oncol 1995; 13: 2547–2555.

    Article  CAS  Google Scholar 

  6. De la Rubia J, Martínez C, Solano C et al. Administration of recombinant human granulocyte colony-stimulating factor to normal donors: results of the Spanish National Donor Registry. Bone Marrow Transplant 1999; 24: 723–728.

    Article  CAS  Google Scholar 

  7. Schmitz N, Dreger P, Suttorp M et al. Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor). Blood 1995; 85: 1666–1672.

    CAS  Google Scholar 

  8. Neben S, Hemman S, Montgomery M et al. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. Exp Hematol 1993; 21: 156–162.

    CAS  Google Scholar 

  9. Drake M, Ranaghan L, Morris TCM et al. Analysis of the effect of prior therapy on progenitor cell yield: use of a chemotherapy scoring system. Br J Haematol 1997; 98: 745–749.

    Article  CAS  Google Scholar 

  10. Gandhi MK, Jestice K, Scott MA et al. The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. Bone Marrow Transplant 1999; 23: 9–13.

    Article  CAS  Google Scholar 

  11. Clark RE, Brammer CG . Previous treatment predicts the efficiency of blood progenitor cell mobilization: validation of a chemotherapy scoring system. Bone Marrow Transplant 1998; 22: 859–863.

    Article  CAS  Google Scholar 

  12. Dreger P, Klöss M, Petersen B et al. Autologous progenitor cell transplantation: previous exposure to stem cell-toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts. Blood 1995; 86: 3970–3978.

    CAS  Google Scholar 

  13. Lee JL, Kim SB, Lee GW et al. Collection of peripheral blood progenitor cells: analysis of factors predicting the yields. Transfusion Apher Sci 2003; 29: 29–31.

    Article  Google Scholar 

  14. De Vita VT, Carbone PP, Owens Jr AH et al. Clinical trials with 1,3-bis(2-chloroethyl)-1-nitrosurea, NSC-409962. Cancer Res 1965; 25: 1876–1885.

    CAS  PubMed  Google Scholar 

  15. Tew KD, Colvin M, Chabner BA . Alkylating agents. In: Chabner BA, Longo DL (eds). Cancer Chemotherapy and Biotherapy, 2nd edn. Lippincott-Raven Publishers: Philadelphia, 1996, pp 297–332.

    Google Scholar 

  16. Watts MJ, Sullivan AM, Jamieson E et al. Progenitor-cell mobilization after low-dose cyclophosphamide and granulocyte colony-stimulating factor: an analysis of progenitor-cell quantity and quality and factors predicting for these parameters in 101 pretreated patients with malignant lymphoma. J Clin Oncol 1997; 15: 535–546.

    Article  CAS  Google Scholar 

  17. Siena S, Schiavo R, Pedrazzoli P, Carlo-Stella C . Therapeutic relevance of CD34 cell dose in blood cell transplantation for cancer therapy. J Clin Oncol 2000; 18: 1360–1377.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cell Therapy Area, Clínica Universitaria de Navarra, Pamplona, Spain

    J Pérez-Calvo, J M Aramendia, J Rifón, F Prosper, M Bendandi & E Rocha

  2. Hematology Service, Clínica Universitaria de Navarra, Pamplona, Spain

    J Pérez-Calvo, J Rifón, F Prosper, M Bendandi, E Rocha & S Martin-Algarra

  3. Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Spain

    O Fernàndez, J J Aristu, J M Aramendia & S Martin-Algarra

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  1. J Pérez-Calvo
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  2. O Fernàndez
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Correspondence to J Pérez-Calvo.

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Pérez-Calvo, J., Fernàndez, O., Aristu, J. et al. A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients. Bone Marrow Transplant 33, 499–502 (2004). https://doi.org/10.1038/sj.bmt.1704382

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