Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases

Bone Marrow Transplantation volume 33, pages 103–107 (2004)Cite this article

Summary:

Inflammatory myofibroblastic tumors are benign neoplasms histologically composed of lymphocytes, histiocytes, macrophages, foam cells, and plasma cells among a spindle-shaped stroma. Their etiology and potential for metastatic spread is controversial. Numerous predisposing factors have been suggested, including preceding infections, radiotherapy, and local trauma. We present two cases of pseudotumors that developed in children following hematopoietic stem cell transplantation. These are the first cases after hematopoietic transplant reported in the literature. As these neoplasms are difficult to diagnose and are often confused with highly aggressive tumors, our cases demonstrate that a high index of suspicion for such lesions must be maintained when evaluating masses in post transplant patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Coffin CM, Humphrey PA, Dehner LP . Extrapulmonary inflammatory myofibroblastic tumor. Semin Diagn Pathol 1998; 15: 85–101.

    CAS  PubMed  Google Scholar 

  2. Karnak I, Senocak M, Ciftci A et al. Inflammatory myofibroblastic tumors in children: diagnosis and treatment. J Pediatric Surg 2001; 36: 908–912.

    Article  CAS  Google Scholar 

  3. Coffin C, Watterson J, Priest J, Dehner L . Extrapulmonary inflammatory myofibroblastic tumor. Am J Surg Pathol 1995; 19: 859–872.

    Article  CAS  Google Scholar 

  4. Brunt EM . Benign tumors of the liver. Clin Liver Dis 2001; 5: 1–15.

    Article  CAS  Google Scholar 

  5. Lacaille F, Fournet JC, Sayegh N et al. Inflammatory pseudotumor of the liver: a rare benign tumor mimicking malignancy. Liver Transplant Surg 1999; 5: 83–85.

    Article  CAS  Google Scholar 

  6. Isobe H, Nishi Y, Fukutomi T et al. Inflammatory pseudotumor of the liver associated with acute myelomonocytic leukemia. Am J Gastroenterol 1991; 86: 238–240.

    CAS  PubMed  Google Scholar 

  7. Watanabe K, Tajino T, Sekiguchi M, Suzuki T . Inflammatory myofibroblastic tumor (inflammatory fibrosarcoma) of bone. Arch Pathol Lab Med 2000; 124: 1514–1517.

    CAS  PubMed  Google Scholar 

  8. Baker KS, DeFor TE, Burns LJ et al. New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 2003; 21: 1352–1358.

    Article  Google Scholar 

  9. Oota S, Hitoshi S, Hamagaki M et al. Oral pseudotumor. Cancer 2003; 97: 1353–1357.

    Article  Google Scholar 

  10. Tan K, Thamboo T, Raju G . Xanthomatous pseudotumor. Arch Pathol Lab Med 2003; 127: 739–741.

    PubMed  Google Scholar 

  11. Fujimaki K, Maruta A, Yoshida M et al. Immune reconstitution assessed during five years after allogenic bone marrow transplantation. Bone Marrow Transplant 2001; 27: 1275–1281.

    Article  CAS  Google Scholar 

  12. Sugita K, Soiffer R, Murray C et al. The phenotype and reconstitution of immunoregulatory T cell subsets after T cell-depleted allogenic and autologous bone marrow transplantation. Transplantation 1994; 57: 1465–1473.

    Article  CAS  Google Scholar 

  13. Shenoy S, Mohanakumar T, Todd G et al. Immune reconstitution following allogeneic peripheral stem cell transplants. Bone Marrow Transplant 1999; 23: 335–346.

    Article  CAS  Google Scholar 

  14. Kamani N, Kattamis A, Carroll A, Bunin N . Immune reconstitution after autologous purged bone marrow transplantation in children. J Pediatr Hematol Oncol 2000; 22: 13–19.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the families of JM and BC for their permission in the submission of this report. We thank Dr Brent Adler and Brad Hoehne for technical assistance.

Author information

Authors and Affiliations

  1. The Center for Cancer Research, Columbus Children's Research Institute, The Ohio State University, Columbus, OH, USA

    J Fangusaro, K Klopfenstein & R A Altura

  2. Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J Fangusaro, K Klopfenstein & R A Altura

  3. Department of Surgery, Columbus Children's Hospital and College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J Groner

  4. Department of Biopathology, Columbus Children's Hospital and College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    S Hammond

Authors
  1. J Fangusaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K Klopfenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J Groner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Hammond
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R A Altura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R A Altura.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fangusaro, J., Klopfenstein, K., Groner, J. et al. Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases. Bone Marrow Transplant 33, 103–107 (2004). https://doi.org/10.1038/sj.bmt.1704292

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704292

Keywords

This article is cited by

Search

Advanced search

Quick links