Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Platelet Antigens

Influence of human platelet antigen match on the success of stem cell transplantation after myeloablative conditioning

Bone Marrow Transplantation volume 32, pages 821–824 (2003)Cite this article

Summary:

Mismatches between donor and recipient for human platelet antigens (HPA) may affect the success of transplantation due to: (a) serving as minor histocompa-tibility antigens and therefore render recipients at risk for graft-versus-host disease (GvHD), (b) inhibition of thrombopoiesis due to platelet antibodies. We therefore evaluated the occurrence of GvHD and need of platelet support by prospective analysis of donor–recipient pairs (n=53) for HPA-1, -2, -3, and -5 allotypes and screening for platelet antibodies prior to transplantation and in weekly intervals until day 100 after transplantation. Neither the incidence of GvHD nor the onset of thrombopoiesis, nor the CCI after platelet transfusions, nor the frequency of platelet transfusions was affected by HPA mismatches. Settings of homozygous donors vs heterozygous recipients or homozygous recipients vs heterozygous donors were not associated with any adverse effects on the outcome of the transplantation. Thus, the HPA-match does not affect the success of transplantation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Benjamin RJ, Mc Gurk S, Ralston MS et al. ABO incompati-bility as an adverse risk factor for survival after allogeneic bone marrow transplantation. Transfusion 1999; 39: 179–197.

    Article  CAS  PubMed  Google Scholar 

  2. Rowley SD, Liang PS, Ulz L . Transplantation of ABO-incompatible bone marrow and peripheral blood stem cell components. Bone Marrow Transplant 2000; 26: 749–757.

    Article  CAS  PubMed  Google Scholar 

  3. Worel N, Greinix HT, Schneider B et al. Regeneration of erythropoiesis after related- and unrelated-donor BMT or peripheral blood HPC transplantation: a major ABO mismatch means problems. Transfusion 2000; 40: 543–550.

    Article  CAS  PubMed  Google Scholar 

  4. Goulmy E . Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immuno-therapy. Immunol Rev 1997; 157: 124–140.

    Article  Google Scholar 

  5. Bussel JB, Kunicki TJ, Michelson AD . Platelets: new understanding of platelet glycoproteins and their role in disease. In: American Society for Hematology. Hematology, Education Program BookPlease place editors. 2000, pp 222–240.

    Article  Google Scholar 

  6. Santoso S, Kiefel V . Human platelet alloantigens. Wien Klin Wochenschr 2001; 113: 806–813.

    CAS  PubMed  Google Scholar 

  7. Sperr WR, Huber K, Roden M et al. Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Thromb Res 1998; 90: 117–123.

    Article  CAS  PubMed  Google Scholar 

  8. Santoso J, Kunicki TJ, Kroll H et al. Association of the platelet glycoprotein Ia C807 T gene polymorphism with nonfatal myocardial infarction in younger patients. Blood 1999; 93: 2449–2453.

    CAS  PubMed  Google Scholar 

  9. Anvari A, Janisiw M, Turel Z et al. Platelet glycoprotein Ia gene dimorphism alpha 2-807 in malignant arrhythmia in coronary artery disease. Thromb Res 2000; 98: 281–286.

    Article  CAS  PubMed  Google Scholar 

  10. Juji T, Watanabe Y, Ishikawa Y et al. Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. Tissue Antigens 1999; 54: 229–234.

    Article  CAS  PubMed  Google Scholar 

  11. Panzer S, Kiefel V, Bartram CR et al. Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti-PlA1 specificity: evidence for a host-derived immune reaction. Br J Haematol 1989; 71: 259–264.

    Article  CAS  PubMed  Google Scholar 

  12. Bierling P, Pignon JM, Kuentz M et al. Thrombocytopenia after bone marrow transplantation caused by a recipient origin Br(a) allo-antibody: presence of mixed chimerism 3 years after the graft without hematologic relapse. Blood 1994; 83: 274–279.

    CAS  PubMed  Google Scholar 

  13. Klüter H, Fehlau K, Panzer S et al. Rapid typing for human platelet antigen systems-1, -2, -3, and-5 by PCR amplification with sequence-specific primers. Vox Sang 1996; 71: 121–125.

    PubMed  Google Scholar 

  14. Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C . Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood 1987; 70: 1722–1726.

    CAS  PubMed  Google Scholar 

  15. Kurz M, Knoebl P, Kalhs P et al. Platelet-reactive HLA antibodies associated with low post transfusion platelet increments: a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity test. Transfusion 2001; 41: 771–774.

    Article  CAS  PubMed  Google Scholar 

  16. Platelet and granulocyte antigens and antibodies. In: Brecher ME (ed.). Technical ManualAuthor group/editors/place/publ., 14th edn, American Association of Blood Banks: Bethesda, MD, USA, p 347.

  17. Holensteiner A, Walchshofer S, Adler A et al. Human platelet antigen gene frequencies in the Austrian population. Haemo-stasis 1995; 25: 133–136.

    CAS  Google Scholar 

  18. Leeksma OC, Giltay JC, Zandbergen-Spaargaren J et al. The platelet alloantigen Zwa or PlA1 is expressed by cultured endothelial cells. Br J Haematol 1987; 66: 369–373.

    Article  CAS  PubMed  Google Scholar 

  19. Giltay JC, Brinkmann HJM, Vlekke A et al. The platelet glycoprotein IaIIa associated Br alloantigen system is expressed by cultured endothelial cells. Br J Haematol 1990; 75: 557–560.

    Article  CAS  PubMed  Google Scholar 

  20. Wernet D, Hinnak N, Schnaidt M . Reactivation of antibodies of donor and recipient origin to platelet antigens early after allogeneic bone marrow transplantation: a case report. Br J Haematol 1994; 88: 615–617.

    Article  CAS  PubMed  Google Scholar 

  21. Taaning E, Jacobsen N, Morling N . Graft-derived anti HPA-2b production after allogeneic bone-marrow transplantation. Br J Haematol 1994; 86: 651–653.

    Article  CAS  PubMed  Google Scholar 

  22. Minchinton RM, Waters AH, Kendra J, Barrett AJ . Autoimmune thrombocytopenia acquired from an allogeneic bone-marrow graft. Lancet 1982; 2: 627–629.

    Article  CAS  PubMed  Google Scholar 

  23. Minchinton RM, Waters AH, Malpas JS et al. Platelet- and granulocyte-specific antibodies after allogeneic and autologous bone marrow grafts. Vox Sang 1984; 46: 125–135.

    Article  CAS  PubMed  Google Scholar 

  24. Leitner GC, Stiegler G, Hetz H et al. Post-transfusion purpura without detectable antibodies: their adsorption from the plasma by multiple incompatible platelet transfusions. Br J Hematol 2002; 117: 994–995.

    Article  CAS  Google Scholar 

  25. Bizzaro N, Dianese G . Neonatal alloimmune amegakaryo-cytosis. Case report. Vox Sang 1988; 54: 112–114.

    CAS  PubMed  Google Scholar 

  26. Ballem PJ, Segal GM, Stratton JR et al. Mechanism of thrombocytopenia in chronic thrombocytopenic purpura. J Clin Invest 1987; 80: 33–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank Beate Eichelberger and Daniela Koren for expert technical assistance. This work was supported in part by Grant 8647 from the Jubiläumsfonds from the Oesterreichischen National Bank.

Author information

Authors and Affiliations

  1. Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna, Vienna, Austria

    G C Leitner, A Tanzmann, G Stiegler, P Hoecker & S Panzer

  2. Department of Internal Medicine I, Bone Marrow Transplantation Unit, University of Vienna, Vienna, Austria

    P Kalhs & H T Greinix

Authors
  1. G C Leitner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Tanzmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Stiegler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Kalhs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H T Greinix
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P Hoecker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Panzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S Panzer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Leitner, G., Tanzmann, A., Stiegler, G. et al. Influence of human platelet antigen match on the success of stem cell transplantation after myeloablative conditioning. Bone Marrow Transplant 32, 821–824 (2003). https://doi.org/10.1038/sj.bmt.1704222

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704222

Keywords

Search

Advanced search

Quick links