Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Plasmacytoma

High-dose melphalan followed by radical radiotherapy for the treatment of massive plasmacytoma of the chest wall

Bone Marrow Transplantation volume 32, pages 759–761 (2003)Cite this article

Summary:

We report three cases of massive chest wall plasmacytoma, each greater than 10 cm in diameter, without evidence of overt myeloma, whom we treated with a combination of VAD chemotherapy consolidated by high-dose melphalan and autologous peripheral blood stem cell transplantation and radical radiotherapy. All three patients completed all components of their therapy without experiencing any major side effects and one patient has had a durable remission. The other two patients have had disease progression but at sites other than the original tumour.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Tsang RW, Gospodarowicz MK, Pintilie M et al. Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys 2001; 50: 113–120.

    Article  CAS  Google Scholar 

  2. Barlogie B, Smith L, Alexanian R . Effective management of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984; 310: 1353–1356.

    Article  CAS  Google Scholar 

  3. McQuaker IG, Haynes AP, Stainer C et al. Stem cell mobilization in resistant or relapsed lymphoma: superior yield of progenitor cells following a salvage regimen comprising ifosphamide, etoposide and epirubicin compared to intermediate-dose cyclophosphamide. Br J Haematol 1997; 98: 228–233.

    Article  CAS  Google Scholar 

  4. Bataille R, Sany J . Solitary myeloma: clinical and prognostic factors of a review of 114 cases. Cancer 1981; 48: 845–851.

    Article  CAS  Google Scholar 

  5. Jackson A, Scarffe JH . Prognostic significance of osteopenia and immunoparesis at presentation in patients with solitary myeloma of bone. Eur J Cancer 1990; 26: 363–371.

    Article  CAS  Google Scholar 

  6. Leibross R, Ha C, Cox J et al. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol 1999; 52: 245–249.

    Article  Google Scholar 

  7. Holland J, Trenkner DA, Wasserman TH, Fineberg B . Plasmacytoma. Treatment results and conversion to myeloma. Cancer 1992; 69: 1513–1517.

    Article  CAS  Google Scholar 

  8. Avilés A, Huerta-Guzman J, Delgado S et al. Improved outcome in solitary bone plasmacytomata with combined therapy. Hematol Oncol 1996; 14: 111–117.

    Article  Google Scholar 

  9. Vianelli N, Tosi P . The irreplaceable image: plasmacytoma with cutaneous and pleural involvement. Haematologica 1999; 84: 559.

    CAS  PubMed  Google Scholar 

  10. Fernandez LA, Couban S, Sy R, Miller R . An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart. Am J Hematol 2001; 67: 194–196.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Haematology, Nottingham City Hospital, Nottingham, UK

    E P Das-Gupta, G M Sidra, R J Lush, J L Byrne & N H Russell

  2. Department of Clinical Oncology, Nottingham City Hospital, Nottingham, UK

    E M Bessell

Authors
  1. E P Das-Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G M Sidra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E M Bessell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R J Lush
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J L Byrne
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N H Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E P Das-Gupta.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Das-Gupta, E., Sidra, G., Bessell, E. et al. High-dose melphalan followed by radical radiotherapy for the treatment of massive plasmacytoma of the chest wall. Bone Marrow Transplant 32, 759–761 (2003). https://doi.org/10.1038/sj.bmt.1704221

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704221

Keywords

This article is cited by

Search

Advanced search

Quick links