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Successful haematopoietic stem cell transplantation from a matched unrelated donor following three graft failures from HLA-mismatched related donors

Bone Marrow Transplantation volume 32, pages 729–731 (2003)Cite this article

Summary:

Graft rejection and graft failure are serious complications after allogeneic stem cell transplantation (SCT). We report a patient with CML in first chronic phase who finally engrafted with a transplant from an HLA-identical unrelated donor after graft failures from two related HLA-mismatched sibling donors. After failure of one BM and two PBSC grafts from two 1 HLA-antigen mismatched related donors, the patient was finally successfully transplanted from a subsequently identified HLA-identical unrelated donor (donor 3). At 5 years post transplant, the patient is in complete cytogenetic and molecular remission.

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Authors and Affiliations

  1. Department of Haematology, Division of Medicine, Oncology, Immunology and Rheumatology, University of Tübingen, Germany

    A Wiesmann, C Faul, L Kanz & H Einsele

  2. Department of Paediatric Haematology, University of Tübingen, Germany

    P Bader

  3. Department of Transfusion Medicine, University of Tübingen, Germany

    M Schnaidt

Authors
  1. A Wiesmann
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  2. P Bader
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  3. C Faul
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  4. M Schnaidt
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  5. L Kanz
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  6. H Einsele
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Correspondence to H Einsele.

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Wiesmann, A., Bader, P., Faul, C. et al. Successful haematopoietic stem cell transplantation from a matched unrelated donor following three graft failures from HLA-mismatched related donors. Bone Marrow Transplant 32, 729–731 (2003). https://doi.org/10.1038/sj.bmt.1704191

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  • DOI: https://doi.org/10.1038/sj.bmt.1704191

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