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Syngeneic graft-versus-host disease: a report of two cases and literature review

Bone Marrow Transplantation volume 32, pages 535–539 (2003)Cite this article

Summary:

Rappeport et al first reported the clinical syndrome of graft-versus-host disease (GVHD) in syngeneic bone marrow transplant patients. Recently, there have been more reports of a GVHD-like syndrome in syngeneic bone marrow transplant patients (SGVHD) that may result in significant clinical morbidity. A total of 17 cases of SGVHD in syngeneic bone marrow transplant patients have been reported to date in the medical literature. The current report reviews these cases and presents two additional cases of severe SGVHD that have occurred at our institution.

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References

  1. Billingham RE, Brent L . A simple method for inducing skin allograft in mice. Transplant Bull 1957; 4: 67.

    CAS  PubMed  Google Scholar 

  2. Deeg HJ, Cottler-Fox M . Clinical spectrum and pathophysiology of graft-versus-host disease. In: Burakoff SJ, Deeg HJ, Ferrara J, Atkinson K (eds). Graft-versus-host Disease: Immunology, Pathophysiology and Treatment. Marcel Dekker: New York, 1990, pp 311–336.

    Google Scholar 

  3. Hess AD, Horowitz L, Beschorner WE et al. Development of graft-versus-host disease like syndrome in cyclosporin-treated rats after syngeneic bone marrow transplant. J Exp Med 1985; 161: 718–730.

    Article  CAS  PubMed  Google Scholar 

  4. Einsele H, Ehninger G, Schneider EM et al. High frequency of graft versus host like syndromes following syngeneic bone marrow transplantation. Transplantation 1988; 45: 579–585.

    Article  CAS  PubMed  Google Scholar 

  5. Rappeport JM, Mihm M, Reinherz E et al. Acute graft-versus-host disease in recipients of bone marrow transplant from identical donors. Lancet 1979; ii: 717–720.

    Article  Google Scholar 

  6. Gluckman E, Devergie A, Sohier J et al. Graft-versus-host disease in recipients of syngeneic bone marrow. Lancet 1980; i: 253–254.

    Google Scholar 

  7. Hood AF, Vogelsang GB, Black LP et al. Acute graft-versus-host disease, development following autologous and syngeneic bone marrow transplantation. Arch Dermatol 1987; 123: 745–750.

    Article  CAS  PubMed  Google Scholar 

  8. Deane M, Singer C, Lawler M et al. Acute skin GVHD following syngeneic BMT for CLL. Bone Marrow Transplant 1998; 22: 1207–1209.

    Article  CAS  PubMed  Google Scholar 

  9. Hwang WY, Goh YT, Tan CH et al. Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy. Bone Marrow Transplant 2000; 25: 205–207.

    Article  CAS  PubMed  Google Scholar 

  10. Wolin MJ, Rigor RL . Acute graft-versus-host disease in a recipient of a twin blood cell transplant. Bone Marrow Transplant 1996; 17: 125–126.

    CAS  PubMed  Google Scholar 

  11. Spaner D, Lowsky R, Fyles G et al. Acute intestinal graft-versus-host disease in a syngeneic bone marrow transplant recipient. Transplantation 1998; 66: 1251–1253.

    Article  CAS  PubMed  Google Scholar 

  12. Billingham RE . The biology of graft-versus-host reaction. Harvey Lect 1966–67; 62: 21–78.

    PubMed  Google Scholar 

  13. Ferrara JLM, Deeg HJ . Graft-versus-host disease. N Engl J Med 1991; 324: 667–674.

    Article  CAS  PubMed  Google Scholar 

  14. Sale GE, Lerner KG, Barker EA et al. The skin biopsy in the diagnosis of graft-versus-host disease in man. Am J Pathol 1977; 89: 621–636.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Glazier A, Tutschka PJ, Farmer ER et al. Graft-versus-host disease in cyclosporin A treated rats after syngeneic and autologous bone marrow transplant. J Exp Med 1983; 158: 1–8.

    Article  CAS  PubMed  Google Scholar 

  16. Gao EK, Lo D, Cheney RT et al. Abnormal differentiation of thymocytes in mice treated with cyclosporine A. Nature 1988; 336: 176.

    Article  CAS  PubMed  Google Scholar 

  17. Shi Y, Sahai BM, Green DR . Cyclosporine A inhibits activation-induced cell death in T cell hybridomas and thymocytes. Nature 1989; 339: 625.

    Article  CAS  PubMed  Google Scholar 

  18. Cheney RT, Sprent J . Capacity of cyclosporine to induce auto-graft-versus-host disease and impair intrathymic T cell differentiation. Transplant Proc 1985; 17: 528.

    CAS  Google Scholar 

  19. Ferrara J, Burakoff S . The pathophysiology of graft-versus-host disease in a murine bone marrow transplant model. In: Burakoff SJ, Deeg HJ, Ferrara J, Atkinson K (eds). Graft-versus-host Disease: Immunology, Pathophysiology and Treatment. Marcel Dekker: New York, 1990, pp 9–29.

    Google Scholar 

  20. Sale GE, Shulman HM, Hackman RC . Pathophysiology of bone marrow transplantation. In: Forman SJ, Blume KG, Thomas Ed (eds). Pathology of Bone Marrow Transplantation. Blackwell Scientific Publications: Boston, MA, 1994, p 189.

    Google Scholar 

  21. Biddeson WE, Shaw S, Nelson DL . Virus specificity of human influenza virus immune cytotoxic T cells. J Immunol 1979; 122: 660–664.

    Google Scholar 

  22. Drobyski W, Thibodeau S, Truitt RL et al. Third party mediated graft rejection and graft-versus-host disease after T cell depleted bone marrow transplant as demonstrated by hypervariable DNA probes and HLA DR polymorphism. Blood 1989; 74: 2285–2294.

    CAS  PubMed  Google Scholar 

  23. Anderson KC, Weinstein HJ . Transfusion-associated graft-versus-host disease. N Engl J Med 1990; 323: 315–321.

    Article  CAS  PubMed  Google Scholar 

  24. Jones R, Vogelsang GB, Hess A et al. Induction of graft-versus-host disease after autologous bone marrow transplantation. Lancet 1989; 1: 754–757.

    Article  CAS  PubMed  Google Scholar 

  25. Morris LE, Vogelsang GB, Bright E et al. Immune reconstitution in cyclosporine A induced autologous graft-versus-host disease. Blood 1992; 80 (Suppl 1): 534 (Abstr.).

    Google Scholar 

  26. Kennedy MJ . Induced autologous graft-versus-host disease for treatment of cancer. Cancer Treatment Rev 1994; 20: 97–103.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland, OH, USA

    T Latif, B Pohlman, M Kalaycio, R Sobecks, S Andresen & B J Bolwell

  2. Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH, USA

    E D Hsi

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  1. T Latif
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  2. B Pohlman
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  3. M Kalaycio
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  4. R Sobecks
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  6. S Andresen
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  7. B J Bolwell
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Latif, T., Pohlman, B., Kalaycio, M. et al. Syngeneic graft-versus-host disease: a report of two cases and literature review. Bone Marrow Transplant 32, 535–539 (2003). https://doi.org/10.1038/sj.bmt.1704171

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