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Post-Transplant Complications

FK506-associated limbic injury following umbilical cord blood transplantation

Bone Marrow Transplantation volume 32, pages 523–525 (2003)Cite this article

Summary:

A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.

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Authors and Affiliations

  1. Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

    Y Yoshida, H Shimada, T Mori, H Yoshihara, M Takeoka & T Takahashi

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  1. Y Yoshida
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  2. H Shimada
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  3. T Mori
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  4. H Yoshihara
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  5. M Takeoka
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  6. T Takahashi
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Yoshida, Y., Shimada, H., Mori, T. et al. FK506-associated limbic injury following umbilical cord blood transplantation. Bone Marrow Transplant 32, 523–525 (2003). https://doi.org/10.1038/sj.bmt.1704168

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  • DOI: https://doi.org/10.1038/sj.bmt.1704168

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