Summary:
This study was performed to investigate whether measurement of cyclic GMP (cGMP), a marker for nitric oxide production, before and after allogeneic bone marrow transplantation (BMT) with total body irradiation (TBI) conditioning was of prognostic value. cGMP levels were monitored in 23 consecutive patients who received TBI as conditioning for BMT, and were compared with the outcome. cGMP became positive during the aplastic phase after BMT in 12 patients. In nine of these 12 patients, cGMP level decreased during the recovery phase. Eight of the nine patients survived, one dying after relapse. In three other patients, the cGMP level continued to increase even during the recovery phase and they died of severe complications. cGMP became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 patients, respectively. Subsequently, all patients died of severe complications. The two patients who were negative for cGMP both before and after BMT survived without complications. These results suggest that monitoring cGMP from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Takatsuka H, Wakae T, Mori A et al. Effects of total body irradiation on the vascular endothelium. Clin Transplant 2002; 16: 374–377.
Chao NJ, Schmidt GM, Nilanjd JC et al. Cyclosporin, methotrexate and prednisone compared with cyclosporin and prednisone for prophylaxis of acute graft-versus-host disease. N Engl J Med 1993; 329: 1225–1230.
Palmer RMJ, Ferrige AG, Moncada S . Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–526.
Palmer RM, Ashton DS, Moncada S . Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664–666.
Hattori Y, Campbell EB, Gross SS . Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis. J Biol Chem 1994; 269: 9405–9408.
Rees DD, Cellek S, Palmer RM et al. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem Biophys Res Commun 1990; 173: 541–547.
Schulz R, Smith JA, Lewis MJ et al. Nitric oxide synthase in cultured endocardial cells of the pig. Br J Pharmacol 1991; 104: 21–24.
Akaike T, Noguchi Y, Ijiri S et al. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 1996; 93: 2448–2453.
Gaginella TS, Kachur JF, Tamai H et al. Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. Gastroenterology 1995; 109: 2019–2028.
Marumo T, Nakaki T, Hishikawa K et al. Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. Hypertension 1995; 25: 764–768.
Takatsuka H, Takemoto Y, Yamada S et al. Complications after bone marrow transplantation are manifestation of systemic inflammatory response syndrome. Bone Marrow Transplant 2000; 26: 419–426.
Acknowledgements
We thank Ms R Tanaka for her expert technical assistance.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takatsuka, H., Wakae, T., Mori, A. et al. Prognostic value of cyclic GMP in patients undergoing allogeneic bone marrow transplantation after conditioning with total body irradiation. Bone Marrow Transplant 31, 905–908 (2003). https://doi.org/10.1038/sj.bmt.1703956
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703956
