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Successful treatment of refractory T-cell acute lymphoblastic leukemia by unmanipulated stem cell transplantation from an HLA 3-loci mismatched (haploidentical) sibling

Bone Marrow Transplantation volume 31, pages 507–510 (2003)Cite this article

Summary:

We describe a patient with refractory T-cell acute lymphoblastic leukemia who successfully underwent unmanipulated stem cell transplantation from an HLA 3-loci mismatched (haploidentical) sibling. In order to avoid severe graft-versus-host disease (GVHD), we used intensified GVHD prophylaxis consisting of tacrolimus, a short course of methotrexate, methylprednisolone, and mycophenolate mofetil. Hematopoietic reconstitution was rapid, with neutrophil count >5 × 108/l on day +16, and platelet count >2 × 1010/l on day +25. There was no evidence of clinical acute GVHD. Bacterial, fungal, and viral infections were well controlled with antibiotics. The patient is still in complete remission past day +400. We suggest that unmanipulated HLA-mismatched transplantation with intensified GVHD prophylaxis is an alternative option for patients who do not have an HLA-identical donor.

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Authors and Affiliations

  1. Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan

    K Ikegame, Y Tanji, N Kitai, H Tamaki, M Kawakami, T Fujioka, Y Oka & H Ogawa

  2. HLA Laboratory, Kyoto, Japan

    E Maruya & H Saji

  3. Department of Clinical Laboratory Science, Osaka University Medical School, Japan

    H Sugiyama

Authors
  1. K Ikegame
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  2. Y Tanji
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  3. N Kitai
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  4. H Tamaki
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  5. M Kawakami
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  6. T Fujioka
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  7. Y Oka
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  8. E Maruya
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  9. H Saji
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  10. H Sugiyama
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  11. H Ogawa
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Ikegame, K., Tanji, Y., Kitai, N. et al. Successful treatment of refractory T-cell acute lymphoblastic leukemia by unmanipulated stem cell transplantation from an HLA 3-loci mismatched (haploidentical) sibling. Bone Marrow Transplant 31, 507–510 (2003). https://doi.org/10.1038/sj.bmt.1703858

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  • DOI: https://doi.org/10.1038/sj.bmt.1703858

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