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Safety and efficacy of high-dose G-CSF (24 μg/kg) alone for PBSC moblization in children

Bone Marrow Transplantation volume 30, pages 987–988 (2002)Cite this article

Good mobilization is essential for PBSC collection with a minimum number of aphereses. Mobilization failures and repeated apheresis sessions are particularly undesirable in children, as they usually require central venous accesses which cause discomfort and can be complicated with infection if carried for a long period of time while trying new mobilization schemes. Also, repeated and prolonged apheresis sessions are not well tolerated by children.

It is therefore of great interest to develop mobilization schemes for children that ensure PBSC collections with a minimum number of aphereses. Also, as double or triple transplants are increasingly been used in children, it is often necessary to obtain great numbers of PBSC. It would be desirable to obtain them with only one apheresis session.

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References

  1. Engelhardt M, Bertz H, Afting M et al. High- versus standard-dose filgrastim (rhG-CSF) for mobilization of peripheral-blood progenitor cells from allogeneic donors and CD34+ immunoselection J Clin Oncol 1999 17: 2160 2172

    Article  CAS  Google Scholar 

  2. Demirer T, Ayui M, Ozcan M et al. Mobilization of peripheral blood stem cells with chemotherapy and recombinant human granulocyte colony-stimulating factor (rhG-CSF): a randomized evaluation of different doses of rhG-CSF Br J Haematol 2002 116: 468 474

    Article  CAS  Google Scholar 

  3. Halle P, Kanold J, Rapatel C et al. Granulocyte colony-stimulating factor alone at 20 μg/kg vs 10 μg/kg for peripheral blood stem cell mobilization in children Pediatr Transplant 2000 4: 285 288

    Article  CAS  Google Scholar 

  4. Kröger N, Renges H, Krüger W et al. A randomized comparison of once versus twice daily recombinant human granulocyte colony-stimulating factor (filgrastim) for stem cell mobilization in healthy donors for allogeneic transplantation Br J Haematol 2000 111: 761 765

    Google Scholar 

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  1. Service of Hematology, Hospital Sant Joan de Déu, Passeig Saint Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain

    B Pérez-Dueñas, I Alcorta, J Estella, S Rives, T Toll & E Tuset

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  1. B Pérez-Dueñas
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  2. I Alcorta
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  3. J Estella
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Pérez-Dueñas, B., Alcorta, I., Estella, J. et al. Safety and efficacy of high-dose G-CSF (24 μg/kg) alone for PBSC moblization in children. Bone Marrow Transplant 30, 987–988 (2002). https://doi.org/10.1038/sj.bmt.1703723

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