Abstract
The severe form of leukocyte adhesion deficiency type I (LAD-I) usually leads to death early in life. Allogeneic haematopoietic transplantation is the only cure. Unrelated transplantation has been reported only once. We describe three children with LAD-I transplanted with T cell non-depleted bone marrow from unrelated HLA-matched donors. All patients engrafted, one of them at second transplant. One patient developed grade I and one grade II acute GVHD. Two patients are alive, one of them with a decrease in CD11/CD18 expression. Early referral for HLA-matched unrelated BMT is a reasonable option for patients with LAD-I lacking an HLA-matched related donor.
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Farinha, N., Duval, M., Wagner, E. et al. Unrelated bone marrow transplantation for leukocyte adhesion deficiency. Bone Marrow Transplant 30, 979–981 (2002). https://doi.org/10.1038/sj.bmt.1703719
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DOI: https://doi.org/10.1038/sj.bmt.1703719
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