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Response to Mielcarek et al

Bone Marrow Transplantation volume 30, page 548 (2002)Cite this article

We thank Mielcarek et al for pointing out possible limitations of our study; most of which in fact we had acknowledged in the paper:1 ‘This observation has been made in a relatively small group of patients and needs to be validated. It is not known if this observation holds true for other diagnoses, disease stages, alternative donors or PBSCT’, and ‘With the conflicting data in the literature, it is clear that further work is necessary to determine the effects of ABO incompatibility on the outcome of relatively homogeneous groups of patients allografted using marrow’.

The P values shown in Table 3 represented overall comparisons of ABO-matched, minor mismatched and major mismatched groups (P = 0.086 for relapse). When the minor and major mismatched groups were compared separately with the matched group, the difference in relapse rates was significant for minor/bidirectional mismatches (P = 0.051), but not for major (P = 0.22) – which is in keeping with the graft-versus-host direction isohemagglutinins seen in minor/bidirectional mismatches.

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References

  1. Mehta J, Powles R, Sirohi B et al. Does donor–recipient ABO incompatibility protect against relapse after allogeneic bone marrow transplantation in first remission acute myeloid leukemia? Bone Marrow Transplant 2002 29: 853 859

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  2. Mielcarek M, Leisenring W, Torok-Storb B et al. Graft-versus-host disease and donor-directed hemagglutinin titers after ABO-mismatched related and unrelated marrow allografts: evidence for a graft-versus-plasma cell effect Blood 2000 96: 1150 1156

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  1. Division of Hematology/Oncology, Northwestern University Medical School, 676 N St Clair Street, Suite 850, Chicago, IL 60611, USA

    J Mehta

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Mehta, J. Response to Mielcarek et al. Bone Marrow Transplant 30, 548 (2002). https://doi.org/10.1038/sj.bmt.1703707

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