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Clonal expansion of limited T cell clonotypes in affected muscle from a patient with post-transplant polymyositis

Bone Marrow Transplantation volume 30, pages 467–470 (2002)Cite this article

Abstract

Critical roles of T cells in idiopathic polymyositis have been suggested, but, those in polymyositis occurring as GVHD after BMT are poorly understood. We thus investigated T cell clonality in a patient with post- transplant polymyositis. As a result, T cell receptor β chains used various BV families in peripheral blood, but only one BV family (BV7) in affected muscle. Importantly, T cells proliferated oligoclonally both in the peripheral blood and the muscle, however, the expanded clonotypes were completely different. Taken together, T cells expanded in the muscle, possibly stimulated by limited kinds of antigens, may drive myositis.

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Acknowledgements

We thank Ms Sayaka Yukii and Ms Yumiko Ajiri for their technical assistant. This work was supported in part by grants from the Ministry of Health and Welfare and the Ministry of Education of Japan.

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Authors and Affiliations

  1. The Second Department of Medicine and the Second Department of Pathology, Okayama University Medical School, Okayama, Japan

    K Kojima, M Harada & M Tanimoto

  2. Rheumatology, Immunology and Genetic Program, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan

    MS Kurokawa, K Nishioka & T Kato

  3. Research Institute for Clinical Pharmacology, The Kitasato Institute, Tokyo, Japan

    MS Kurokawa

  4. Division of Haematology, Ehime Prefectural Central Hospital, Matsuyama, Japan

    K Tanimoto, Y Kojima & M Hara

  5. The Second Department of Pathology, Okayama University Medical School, Okayama, Japan

    T Yoshino

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  1. K Kojima
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Kojima, K., Kurokawa, M., Tanimoto, K. et al. Clonal expansion of limited T cell clonotypes in affected muscle from a patient with post-transplant polymyositis. Bone Marrow Transplant 30, 467–470 (2002). https://doi.org/10.1038/sj.bmt.1703665

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  • DOI: https://doi.org/10.1038/sj.bmt.1703665

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