Abstract
In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after unrelated cord blood transplantation. Monitoring the BP-specific circulating antibodies and CD25-expressing activated T lymphocyte subset led us to combine anti-CD20 (Rituximab) mediated B cell ablation with anti-CD25 (Daclizumab) therapy to block CD4+ T cell help. Complete clinical and serologic response was achieved within 4 weeks of initiation of therapy allowing global immunosuppression to be dramatically reduced.
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Acknowledgements
This work was supported in part by The Lisa Stafford Memorial Research Prize, The National Marrow Donor Program-Marrow Transplant Research Grant (PSz), RO1-Al-47258-01A1 (RH), N01-HB-67141, N01-HB-67138 (JK).
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Szabolcs, P., Reese, M., Yancey, K. et al. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant 30, 327–329 (2002). https://doi.org/10.1038/sj.bmt.1703654
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DOI: https://doi.org/10.1038/sj.bmt.1703654
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