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Transplantation for accidental acute high-dose total body neutron- and γ-radiation exposure

Bone Marrow Transplantation volume 29, pages 935–939 (2002)Cite this article

Abstract

Accidental exposure to acute high-dose total body neutron radiation is rare. We report a 35-year-old man exposed to a total body dose of 5.4 Gy neutron- and 8.5–13 Gy γ-radiation in a radiation criticality accident. He received a blood stem cell transplant from his HLA-identical sister. There was bone marrow recovery with complete donor chimerism. Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multi-organ failure.

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References

  1. IAEA Safety Reports Series No 4 Planning the medical response to Radiological Accidents International Atomic Energy Agency: Vienna 1998

  2. Medical Research Council's Committee on Effects of lonizing Radiation. Lethality from acute and protracted radiation exposure in man Intl J Rad Biol 1984 46: 209 217

  3. Mettler FAJ, Moseler RDJ . Medical Effects of Ionizing radiation Grune & Stratton: Orlando, FL 1985

    Google Scholar 

  4. United Nations Scientific Committee on the Effects of Atomic Radiation. Report to the General Assembly, Annex G. Early effects in man of high doses of radiation United Nations: New York 1988

  5. Jammet HP . Treatment of victims of the zeroenergy reactor accident in Vinca. Diagnosis and Treatment of Acute Radiation Injury International Document Servis: New York 1961; pp. 83–103

    Google Scholar 

  6. Gilberti MV . The 1967 radiation accident near Pittsburgh, Pennsylvania, and a follow-up report. In: Hubner KF, Fry SA (eds) The Medical Basis for Radiation Accident Preparedness: Proceedings of the REAC/TS International Conference: the Medical Basis for Radiation Accident Preparedness, October 18–20, 1979, Oak Ridge, Tennessee Elsevier/North-Holland: New York 1980 131 140

    Google Scholar 

  7. Gen-yao T, Yong L, Nue T, Ben-yun C et al. The People's Republic of China accident in 1963. In: Hubner KF, Fry SA (eds). The Medical Basis for Radiation Accident Preparedness: Proceedings of the REAC/TS International Conference: the Medical Basis for Radiation Accident Preparedness, October 18–20, 1979, Oak Ridge, Tennessee Elsevier/North-Holland: New York 1980; pp. 81–89

    Google Scholar 

  8. Baranov A, Gale RP, Guskova A et al. Bone marrow transplantation after the Chernobyl nuclear accident New Engl J Med 1989 321: 205 212

    Article  CAS  Google Scholar 

  9. International Atomic Energy Agency. The Radiological Accident in Soreq International Atomic Energy Agency: Vienna 1993

  10. Gale RP . The role of bone marrow transplantation following nuclear accidents Bone Marrow Transplant 1987 2: 1 6

    CAS  PubMed  Google Scholar 

  11. Baranov AE, Konchalovski MV, Soloviev WY, Guskova AK . Use of blood cell count changes after radiation exposure in dose assessment and evaluation of bone marrow function. In: Ricks RC, Fry SA (eds) The Medical Basis for Radiation Accident Preparedness II Elsevier/North-Holland: New York 1990 427 443

    Google Scholar 

  12. Hayata I, Kanda R, Minamihisamatsu M et al. Cytogenetical dose estimation for 3 severely exposed patients in the criticality accident in Tokai-mura J Radiat Res 2001 42 (Suppl): S149 155

    Article  Google Scholar 

  13. Ishigure N, Endo A, Yamaguchi Y, Kawachi K . Calculation of absorbed dose for the overexposed patients at the JCO criticality accident in Tokai-mura J Radiat Res 2001 42 (Suppl): S137 148

    Article  Google Scholar 

  14. International Atomic Energy Agency. The clinicality accident in Sarov International Atomic Energy Agency: Vienna 2001

  15. Lapidot T, Singer TS, Reisner Y . Transient engraftment of T cell-depleted allogeneic bone marrow in mice improves survival rate following lethal irradiation Bone Marrow Transplant 1988 3: 157 164

    CAS  Google Scholar 

  16. Watson GE, Lorimore SA, Macdonald DA, Wright EG . Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation Cancer Res 2000 60: 5608 5611

    CAS  PubMed  Google Scholar 

  17. Kadhim MA, Macdonald DA, Goodhead DT et al. Transmission of chromosomal instability after plutonium alpha-particle irradiation Nature 1992 355: 738 740

    Article  CAS  Google Scholar 

  18. Morgan WF, Day JP, Kaplan MI et al. Genomic instability induced by ionizing radiation Radiat Res 1996 146: 247 258

    Article  CAS  Google Scholar 

  19. Gale RP . Therapy of bone marrow failure after radiation accidents In: Tsujii H, Akashi M (eds) International Symposium on The Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency National Institute of Radiological Sciences: Chiba 2001 pp 208 211

    Google Scholar 

  20. Pendic B, Barjaktarovic N, Kostic V . Chromosomal aberrations in persons accidentally irradiated in Vinca 19 years ago Radiat Res 1980 81: 478 482

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank members of the Departments of Hematology and Oncology, Critical Care and Thaumatology, Dermatology, Gastroenterology, Nephrology and Endocrinology, Cardiology, Respiratory Diseases, Radiology, and Transfusion Medicine, and nursing staffs of the intensive care unit of the University of Tokyo Hospital, and members of the National Institute of Radiological Sciences, particularly Dr I Hayata for the chromosome analyses. We also thank Drs Y Kanda, S Mineishi, K Nakagawa and T Kinugasa for helpful discussions.

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Authors and Affiliations

  1. Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan

    S Chiba, A Saito, K Kumano & H Hirai

  2. Department of Hematology and Oncology, University of Tokyo Hospital, Tokyo, Japan

    S Ogawa, S Seo, T Suzuki, Y Tanaka, T Saito, K Izutsu, K Yuji & S Masuda

  3. Department of Pathology, University of Tokyo Hospital, Tokyo, Japan

    K Takeuchi & M Fukayama

  4. Department of Critical Care/Trauma, University of Tokyo Hospital, Tokyo, Japan

    S Futami, M Nishida & K Maekawa

  5. Department of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan

    G Suzuki

  6. Center for Advanced Studies in Leukemia, Los Angeles, CA, USA

    RP Gale

Authors
  1. S Chiba
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  2. A Saito
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  3. S Ogawa
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  4. K Takeuchi
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  7. T Suzuki
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  8. Y Tanaka
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  9. T Saito
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  10. K Izutsu
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  11. K Yuji
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  12. S Masuda
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  13. S Futami
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  14. M Nishida
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  15. G Suzuki
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  16. RP Gale
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  17. M Fukayama
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  18. K Maekawa
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  19. H Hirai
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Chiba, S., Saito, A., Ogawa, S. et al. Transplantation for accidental acute high-dose total body neutron- and γ-radiation exposure. Bone Marrow Transplant 29, 935–939 (2002). https://doi.org/10.1038/sj.bmt.1703568

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  • DOI: https://doi.org/10.1038/sj.bmt.1703568

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