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Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration

Bone Marrow Transplantation volume 29, pages 535–536 (2002)Cite this article

Abstract

Cyclosporine A (CsA) may be bound to and released from the inner surface of central venous catheters resulting in spuriously elevated blood drug levels. We observed this phenomenon in a boy transplanted because of aplastic anemia up to 9 weeks after CsA had been switched from intravenous to oral administration. In comparison to phlebotomy, simultaneous blood sampling from the double lumen catheter resulted in a greater than 10-fold, or two-fold increase in drug levels, respectively, depending on whether or not the line used for prior CsA infusion was selected. Thus, prolonged binding of CsA to the inner surface of venous catheters should also be considered during oral administration.

Bone Marrow Transplantation (2002) 29, 535–536. doi:10.1038/sj.bmt.1703399

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Authors and Affiliations

  1. Bone Marrow Transplant Unit, University of Kiel, Kiel, Germany

    A Claviez, B Glass & P Dreger

  2. University of Dresden, Germany

    M Suttorp

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  1. A Claviez
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  2. B Glass
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  3. P Dreger
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  4. M Suttorp
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Claviez, A., Glass, B., Dreger, P. et al. Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration. Bone Marrow Transplant 29, 535–536 (2002). https://doi.org/10.1038/sj.bmt.1703399

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  • DOI: https://doi.org/10.1038/sj.bmt.1703399

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