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Platelet Aggregation

Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation

Bone Marrow Transplantation volume 29, pages 107–111 (2002)Cite this article

Abstract

Cyclosporine A (CsA) may increase the incidence of thrombotic events, but whether tacrolimus (Tc) has such effects is still unclear. The serotonergic system has been linked to the thrombotic effects of CsA, but a direct effect of CsA on serotonin-induced platelet aggregation has not been demonstrated because of methodological difficulties. We measured the effects of CsA and Tc on serotonin-induced platelet aggregate formation by particle counting using light scattering. CsA and Tc both enhanced serotonin-induced formation of small platelet aggregates, however, neither CsA nor Tc affected aggregation induced by high or low concentrations of ADP, with or without addition of a serotonin receptor antagonist. Both CsA and Tc enhance platelet aggregation induced via the serotonin pathway.

Bone Marrow Transplantation (2002) 29, 107–111. doi:10.1038/sj.bmt.1703335

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Authors and Affiliations

  1. Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    A Suehiro, A Sawada, Y Hasegawa, H Takatsuka, S Higasa & E Kakishita

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  1. A Suehiro
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  2. A Sawada
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  5. S Higasa
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Suehiro, A., Sawada, A., Hasegawa, Y. et al. Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. Bone Marrow Transplant 29, 107–111 (2002). https://doi.org/10.1038/sj.bmt.1703335

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