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Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia: graft-versus-leukemia effect without graft-versus-host disease

Bone Marrow Transplantation volume 28, pages 1155–1156 (2001)Cite this article

Abstract

A patient with progressive prolymphocytic leukemia (PLL) received an allogeneic stem cell transplant using a reduced intensity conditioning regimen to avoid prohibitive toxicities. Early in the post-tranplant period, a high donor-derived CD8+ count was observed. One year from transplantation, the patient was in complete remission, fully donor chimeric and with a normal performance status, suggesting that this approach may represent a useful treatment option in patients with refractory PLL.

Bone Marrow Transplantation (2001) 28, 1155–1156.

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Authors and Affiliations

  1. Department of Medical Oncology and Hematology, Instituto Clinico Humanitas, Rozzano, Milan, Italy

    L Castagna, A Nozza, A Bertuzzi, L Siracusano, I Timofeeva & A Santoro

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  1. L Castagna
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  2. A Nozza
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  3. A Bertuzzi
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  4. L Siracusano
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  5. I Timofeeva
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  6. A Santoro
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Castagna, L., Nozza, A., Bertuzzi, A. et al. Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia: graft-versus-leukemia effect without graft-versus-host disease. Bone Marrow Transplant 28, 1155–1156 (2001). https://doi.org/10.1038/sj.bmt.1703309

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  • DOI: https://doi.org/10.1038/sj.bmt.1703309

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