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Hypogonadotrophism fails to prevent severe testicular damage induced by total body irradiation in a patient with beta-thalassaemia major and acute lymphoblastic leukaemia

Bone Marrow Transplantation volume 28, pages 989–991 (2001)Cite this article

Abstract

Radiation and chemotherapeutic drugs for cancer produce prolonged and often irreversible gonadal damage. To determine whether total body irradiation (TBI)-induced gonadal damage can be prevented by suppression of pituitary gonadotrophin levels, we studied a patient with transfusion dependent homozygous beta-thalassaemia and acute lymphoblastic leukaemia (ALL) who underwent one-antigen mismatched related bone marrow transplantation (BMT). Our data showed that despite having hypogonadotrophic hypogonadism (HH) prior to BMT, the patient developed primary testicular failure following the procedure, indicating that hypogonadotrophism failed to offer protection against TBI-induced testicular damage in this patient. Although this is an interesting case report, no firm conclusions can be drawn from a single patient. Bone Marrow Transplantation (2001) 28, 989–991.

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References

  1. Chatterjee R, Goldstone AH . Gonadal damage and effects on fertility in adult patients with haematological malignancy undergoing stem cell transplantation Bone Marrow Transplant 1996 17: 5–11

    CAS  Google Scholar 

  2. Glode LM, Robinson J, Gould SF . Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone Lancet 1981 23: 1132–1134

    Article  Google Scholar 

  3. Meistrich ML . Hormonal stimulation of the recovery of spermatogenesis following chemo- or radiotherapy. Review article APMIS 1998 106: 37–45; discussion 45–46

    Article  Google Scholar 

  4. Morris ID, Shalet SM . Protection of gonadal function from cytotoxic chemotherapy and irradiation Baillieres Clin Endocrinol Metab 1990 4: 97–118

    Article  CAS  Google Scholar 

  5. Chatterjee R, Kottaridis PD, McGarrigle H, Goldstone AH . Reversal of fludarabine-induced testicular damage in a patient with chronic lymphocytic leukaemia (CLL), by suppression of pituitary–testicular axis using gonadotrophin releasing hormone (GnRH) Leuk Lymphoma 2001 41: 213–215

    Article  CAS  Google Scholar 

  6. Kottaridis PD, Peggs K, Lawrence A et al. One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders Bone Marrow Transplant 2000 25: 677–678

    Article  CAS  Google Scholar 

  7. Chatterjee R, Katz M, Oatridge A et al. Selective loss of anterior pituitary volume with severe pituitary–gonadal insufficiency in poorly compliant male thalassemic patients with pubertal arrest Ann NY Acad Sci 1998 850: 479–482

    Article  CAS  Google Scholar 

  8. Gosden RG, Wade JC, Fraser HM et al. Impact of congenital or experimental hypogonadotrophism on the radiation sensitivity of the mouse ovary Hum Reprod 1997 12: 2483–2488

    Article  CAS  Google Scholar 

  9. Low LC . Growth, puberty and endocrine function in beta-thalassaemia major J Pediatr Endocrinol Metab 1997 10: 175–184

    Article  CAS  Google Scholar 

  10. De Sanctis V, Vullo C, Katz M et al. Induction of spermatogenesis in thalassaemia Fertil Steril 1988 50: 969–975

    Article  CAS  Google Scholar 

  11. Lucarelli G, Clift RA, Galimberti M et al. Bone marrow transplantation in adult thalassemic patients Blood 1999 93: 1164–1167

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University College London Hospitals, UK

    R Chatterjee & HH McGarrigle

  2. Department of Haematology, University College London Hospitals, UK

    PD Kottaridis & AH Goldstone

  3. Arch Makarios III Hospital, Nicosia, Cyprus

    A Papatryphonos

Authors
  1. R Chatterjee
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  2. PD Kottaridis
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  3. HH McGarrigle
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  4. A Papatryphonos
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  5. AH Goldstone
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Chatterjee, R., Kottaridis, P., McGarrigle, H. et al. Hypogonadotrophism fails to prevent severe testicular damage induced by total body irradiation in a patient with beta-thalassaemia major and acute lymphoblastic leukaemia. Bone Marrow Transplant 28, 989–991 (2001). https://doi.org/10.1038/sj.bmt.1703256

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  • DOI: https://doi.org/10.1038/sj.bmt.1703256

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