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Allogeneic bone marrow transplantation-mediated transfer of specific immunity against Toxocara canis associated with excessive IgE

Bone Marrow Transplantation volume 28, pages 519–521 (2001)Cite this article

Abstract

A girl with myelodysplastic syndrome (RAEB-T) received HLA-identical bone marrow from her younger brother after myeloablative treatment with busulfan and cyclophosphamide. After bone marrow transplantation, fever, exanthema, pruritis, and a pulmonary infiltrate were treated symptomatically. Bacterial cultures remained negative. Leukocyte engraftment began on day 10, and all blood cell populations proved to be of donor origin on FISH analysis. Increasing IgE levels (21 000 U/ml) on day 14 after BMT, positive RAST, specific IgG-antibodies, and missing Toxocara (T.) canis antigens in the recipient indicated donor-derived seroconversion. Before BMT, the recipient had been negative for T. canis in routine parasitological screening, and the donor proved to be positive for T. canis antibody by ELISA. This report suggests that the transfer of IgE immunity in the absence of detectable antigens may be responsible for IgE-mediated symptoms consistent with toxocara infection and confirms the need for parasite screening in donor medical examinations. Bone Marrow Transplantation (2001) 28, 519–521.

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References

  1. American Academy of Pediatrics. Toxocariasis. In: Pickering LK (ed). 2000 Red Book: Report of the Committee on Infectious Diseases, 25th edn. American Academy of Pediatrics: Elk Grove Village, IL 2000 pp 582–583

  2. Niemeyer C . EWOG-MDS 98: prospective study of the diagnosis and treatment of myelodysplastic syndromes in childhood. Gesellschaft für pädiatrische Onkologie und Hämatologie, Freiburg, Germany

  3. Agosti JM, Sprenger JD, Lum LG et al. Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation New Engl J Med 1988 319: 1623–1628

    Article  CAS  Google Scholar 

  4. Boland GJ, Vlieger AM, Ververs C, De Gast GC . Evidence for transfer of cellular and humoral immunity to cytomegalovirus from donor to recipient in allogeneic bone marrow transplantation Clin Exp Immunol 1992 88: 506–511

    Article  CAS  Google Scholar 

  5. Auer H, Aspöck H . Toxocarose-Forschung in Österreich – Ergebnisse, Probleme, Herausforderungen Mitt Österr Ges Tropenmed Parasitol 1998 20: 17–28

    Google Scholar 

  6. Obwaller A, Jensen-Jarolim E, Auer H et al. Toxocara infestation in humans: symptomatic course of toxocarosis correlates significantly with levels of IgE/anti-IgE immune complexes Parasite Immunol 1988 20: 311–317

    Article  Google Scholar 

  7. Buijs J, Borsboom G, van Gemund JJ et al. Toxocara seroprevalence in 5-year-old elementary shool children: relationship with allergic asthma Am J Epidemiol 1994 140: 839–847

    Article  CAS  Google Scholar 

  8. Geha RS, Rappaport JM, Twarog FJ et al. Increased serum immunoglobulin E levels following allogeneic bone marrow transplantation J Allergy Clin Immunol 1980 66: 78–81

    Article  CAS  Google Scholar 

  9. Ringden O, Persson U, Johansson SG et al. Markedly elevated serum IgE levels following allogeneic and syngeneic bone marrow transplantation Blood 1983 61: 1190–1195

    CAS  PubMed  Google Scholar 

  10. Heyd J, Donnenberg AD, Burns WH et al. Immunoglobulin E levels following allogeneic, autologous, and syngeneic bone marrow transplantation: an indirect association between hyperproduction and acute graft-versus-host disease in allogeneic BMT Blood 1988 72: 442–446

    CAS  PubMed  Google Scholar 

  11. Ilan Y, Nagler A, Adler R et al. Adoptive transfer of immunity to hepatitis B virus after T cell-depleted allogeneic bone marrow transplantation Hepatology 1993 18: 246–252

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. St Anna Children's Hospital, Pediatric Stem Cell Transplantation Unit, Vienna, Austria

    G Fischmeister, W Holter, S Matthes-Martin, W Emminger-Schmidmeier, H Gadner & C Peters

  2. Department of Parasitology, Clinical Institute of Hygiene, University of Vienna, Austria

    H Auer

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  1. G Fischmeister
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  2. W Holter
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  3. S Matthes-Martin
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  4. H Auer
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  5. W Emminger-Schmidmeier
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  6. H Gadner
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  7. C Peters
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Fischmeister, G., Holter, W., Matthes-Martin, S. et al. Allogeneic bone marrow transplantation-mediated transfer of specific immunity against Toxocara canis associated with excessive IgE. Bone Marrow Transplant 28, 519–521 (2001). https://doi.org/10.1038/sj.bmt.1703183

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  • DOI: https://doi.org/10.1038/sj.bmt.1703183

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