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Epstein–Barr virus-related lymphoproliferative disease complicating childhood acute lymphoblastic leukemia: no recurrence after unrelated donor bone marrow transplantation

Bone Marrow Transplantation volume 27, pages 93–95 (2001)Cite this article

Abstract

A 16-year-old boy in complete remission of ALL, undergoing oral maintenance therapy, developed intestinal perforation related to EBV-associated lymphoproliferative disease (LPD). He was successfully managed with surgical resection, acyclovir, immunoglobulins and discontinuation of maintenance therapy. Leukemic marrow relapse occurred 3 months later, treated by polychemotherapy followed by unmanipulated BMT from a matched unrelated EBV seropositive donor. Donor lymphocytes were infused twice after transplant because of delayed immunologic recovery and severe CMV colitis. This was followed by acute GVHD requiring prolonged immunosuppressive treatment. Despite intensive and prolonged immunosuppression, recurrence of LPD was not observed. Following EBV-related LPD, allogeneic BMT can be performed if indicated. Selection of an EBV seropositive donor is of major importance for the prevention of LPD recurrence as the recipient may be protected by passive transfer of EBV-specific cytotoxic T cells. Bone Marrow Transplantation (2001) 27, 93–95.

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Authors and Affiliations

  1. Department of Pediatric Hematology, Hôpital Debrousse, Lyon, France

    C Pondarré, K Kebaili, N Philippe & Y Bertrand

  2. Department of Pathology, Hôpital Debrousse, Lyon, France

    F Dijoud

  3. Department of Surgery, Hôpital Debrousse, Lyon, France

    T Basset

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  1. C Pondarré
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  2. K Kebaili
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  3. F Dijoud
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  4. T Basset
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  5. N Philippe
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  6. Y Bertrand
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Pondarré, C., Kebaili, K., Dijoud, F. et al. Epstein–Barr virus-related lymphoproliferative disease complicating childhood acute lymphoblastic leukemia: no recurrence after unrelated donor bone marrow transplantation. Bone Marrow Transplant 27, 93–95 (2001). https://doi.org/10.1038/sj.bmt.1702727

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  • DOI: https://doi.org/10.1038/sj.bmt.1702727

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