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Treatment of an acyclovir and foscarnet-resistant herpes simplex virus infection with cidofovir in a child after an unrelated bone marrow transplant

Bone Marrow Transplantation volume 26, pages 903–905 (2000)Cite this article

Abstract

Herpes simplex virus (HSV) causes serious problems in immuno-compromised patients such as those receiving a bone marrow transplant (BMT) for a hematological malignancy. Resistance to acyclovir (ACV) is a growing major concern. Foscarnet is a non-thymidine kinase-dependent agent, but the emergence of ACV and foscarnet-resistant HSV requires a new therapeutic approach. We describe a girl treated with cidofovir for a life-threatening ACV-resistant HSV infection after an unrelated BMT for a relapse of an acute myeloblastic leukemia (AML). Bone Marrow Transplantation (2000) 26, 903–905.

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Acknowledgements

We thank Valérie Greene for her English language assistance.

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Authors and Affiliations

  1. Pediatrics, General Hospital, Sallanches, France

    N Blot

  2. Pediatric Hematology and Oncology, Charles Nicolle Hospital, Rouen, France

    P Schneider, P Tron & JP Vannier

  3. Dermatology, Charles Nicolle Hospital, Rouen, France

    P Young

  4. Virology, Charles Nicolle Hospital, Rouen, France

    C Janvresse

  5. ENT, Charles Nicolle Hospital, Rouen, France

    D Dehesdin

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  1. N Blot
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  2. P Schneider
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Blot, N., Schneider, P., Young, P. et al. Treatment of an acyclovir and foscarnet-resistant herpes simplex virus infection with cidofovir in a child after an unrelated bone marrow transplant. Bone Marrow Transplant 26, 903–905 (2000). https://doi.org/10.1038/sj.bmt.1702591

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  • DOI: https://doi.org/10.1038/sj.bmt.1702591

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