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Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 573–576 (2000)Cite this article

Abstract

We describe two patients who developed respiratory syncytial virus (RSV) pneumonia after BMT. One died of RSV pneumonia after three courses of steroid pulse therapy. Surprisingly, RSV antigen was identified in the bronchoalveolar lavage fluid (BALF) obtained post mortem. Steroid pulse therapy might have suppressed anti-RSV immunity, leading to persistent RSV infection for more than 1 month. The other patient received donor lymphocyte infusions (DLI) for relapsed plasma cell leukemia, while having active RSV pneumonia. His respiratory condition improved after DLI, and RSV antigen disappeared in BALF and nasal swabs. DLI might be effective in cases of life-threatening RSV pneumonia. Bone Marrow Transplantation (2000) 26, 573–576.

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Authors and Affiliations

  1. Department of Hematology, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan

    Y Kishi, M Kami, Y Oki, S Miyakoshi, S Morinaga & Y Muto

  2. Otsuka Assay Laboratories, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan

    Y Kazuyama

  3. Department of Respiratory Disease, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan

    M Kawabata

  4. Laboratory of Chemotherapy, Aichi Cancer Center, Tokyo, Japan

    R Suzuki

  5. Bone Marrow Transplantation Team, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    S Mori

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Kishi, Y., Kami, M., Oki, Y. et al. Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation. Bone Marrow Transplant 26, 573–576 (2000). https://doi.org/10.1038/sj.bmt.1702559

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