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Autologous peripheral blood stem cell transplantation using G-CSF combined conditioning in AML patients: delayed platelet recovery and frequent early relapse

Bone Marrow Transplantation volume 26, pages 459–460 (2000)Cite this article

The possibility that G-CSF recruits leukemic cells from the G0 to S phase, which may lead to a greater susceptibility to cytotoxic drugs, such as ara-C, has been suggested in some studies.12 In particular, Harada et al1 reported treatment of 16 AML patients in first complete remission (CR1), where G-CSF combined marrow ablative chemotherapy and autologous blood cell transplantation had resulted in a 5-year event-free survival rate of 74.5% with a median follow-up of 44.5 months. In this study, we referred to the protocol of Harada et al1 to try G-CSF combined marrow ablative chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT), for the treatment of AML patients in CR1. However, our preliminary experience in the six patients showed a delayed platelet recovery and high relapse rate, rather than showing results similar to those of Harada et al.1 The possible causes and the implications of our results are discussed below.

Between January 1997 and March 1998, six AML patients (three children, three adults) in CR1 were autografted at the Departments of Pediatrics, Chonnam National University Hospital and Internal Medicine, Korea University Medical Center. We enrolled those AML patients without abnormal chromosomal findings for this study. The patient characteristics, induction chemotherapy and the method of mobilization are shown in Table 1. After achieving a CR1, all patients received two cycles of consolidation chemotherapy and mobilization. The peripheral blood stem cells were collected by CS3000+ during the recovery phase, following respective consolidation chemotherapy.

Table 1  Main characteristics of the patients before transplantation
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References

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  1. Department of Internal Medicine, Anam Hospital, Korea University Medical Center, 80, Anam-Dong, Seongbuk-Ku, Seoul, Korea

    BS Kim, CW Choi & JS Kim

  2. Department of Pediatrics, Chonnam National University Hospital, Kwangju, Korea

    H Kook, TJ Hwang & CJ Kim

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  1. BS Kim
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  2. H Kook
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Kim, B., Kook, H., Hwang, T. et al. Autologous peripheral blood stem cell transplantation using G-CSF combined conditioning in AML patients: delayed platelet recovery and frequent early relapse. Bone Marrow Transplant 26, 459–460 (2000). https://doi.org/10.1038/sj.bmt.1702513

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