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Late onset cyclosporine-induced cerebral blindness with abnormal SPECT imagings in a patient undergoing unrelated bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 105–108 (2000)Cite this article

Abstract

A 23-year-old woman underwent HLA-matched unrelated BMT for CML. She developed cerebral blindness on day 81. Brain magnetic resonance imaging revealed hyperintensity on a T2-weighted image in the white and gray matter of the right frontal and both occipital lobes. Single-photon emission computed tomography (SPECT) was consistent with a decrease in radionuclide uptake in these areas, suggesting a vasoconstrictive mechanism. A diagnosis of CsA-induced encephalopathy was made and CsA was discontinued. Her vision recovered completely after 24 h and abnormal imaging resolved within 2 weeks. This case demonstrates late onset CsA-induced cerebral blindness with the previously unreported abnormalities on SPECT. Bone Marrow Transplantation (2000) 26, 105–108.

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Acknowledgements

We would like to thank Drs M Funauchi and T Azuma for advice in manuscript preparation. This work was supported in part by the Grant-in-Aid for Cancer Research 10-1 from the Ministry of Health and Welfare.

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Authors and Affiliations

  1. Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    N Uoshima, T Karasuno, T Yagi, S Kawamoto, T Hasegawa, M Yasumi, M Murakami, H Teshima, H Nakamura, A Hiraoka & T Masaoka

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  1. N Uoshima
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  2. T Karasuno
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  3. T Yagi
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  4. S Kawamoto
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  5. T Hasegawa
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  6. M Yasumi
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  7. M Murakami
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  8. H Teshima
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  9. H Nakamura
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  10. A Hiraoka
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  11. T Masaoka
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Uoshima, N., Karasuno, T., Yagi, T. et al. Late onset cyclosporine-induced cerebral blindness with abnormal SPECT imagings in a patient undergoing unrelated bone marrow transplantation. Bone Marrow Transplant 26, 105–108 (2000). https://doi.org/10.1038/sj.bmt.1702467

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  • DOI: https://doi.org/10.1038/sj.bmt.1702467

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