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Response

Bone Marrow Transplantation volume 25, page 1218 (2000)Cite this article

We have read with great interest the above letter from Alessandrino et al ‘Prompt response to high-dose intravenous immunoglobulins given as first-line therapy in post-transplant thrombotic thrombocytopenic purpura’.

They describe the case of a 28-year-old man affected with ALL who underwent an unrelated BMT. On day +94 he developed a TTP syndrome without GVHD, and probably with no CMV infection, grade 2 according to Zeigler's grading system. These data make us think that perhaps the patient did not present a multifactorial TTP post-BMT and that this would be related to CsA. Consequently, CsA was interrupted and high doses of gammaglobulin were administered. Due to the quick complete remission and to the fact that it was an unrelated BMT it may be possible for the patient to restart with CsA before the TTP relapse.

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  1. ITMO-Fundacion Mainette-508, E16 y 18, Gonnet (1897) La Plata, Buenos Aires, Argentina

    J Milone, J Napal, O Etchegoyen & V Morales

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  1. J Milone
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  2. J Napal
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  3. O Etchegoyen
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  4. V Morales
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Milone, J., Napal, J., Etchegoyen, O. et al. Response. Bone Marrow Transplant 25, 1218 (2000). https://doi.org/10.1038/sj.bmt.1702442

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