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Effective high-dose chemotherapy combined with CD34+-selected autologous peripheral blood stem cell transplantation in a patient with cutaneous CD30-negative large T cell lymphoma

Bone Marrow Transplantation volume 25, pages 1315–1317 (2000)Cite this article

Abstract

Generalized multiple cutaneous tumors developed in a 60-year-old Japanese man. Skin biopsy revealed atypical large T lymphocytes infiltrating the dermis. CD30 staining was negative in the tumor cells. The diagnosis of CD30-negative cutaneous large T cell lymphoma was made. Axial and inguinal lymphadenopathy was present, but there was no evidence of bone marrow involvement. Seven cycles of chemotherapy and local electron beam irradiation were administered and complete remission (CR) was attained. As CD30-negative cutaneous large T cell lymphoma has a poor prognosis despite intensive chemotherapy, high-dose chemotherapy followed by CD34+-selected autologous peripheral blood stem cell transplantation (CD34+-APBSCT) was prescribed. The clinical course after CD34+-selected APBSCT was complicated with CMV infection occurring twice but administration of ganciclovir resolved the symptoms. He has remained in CR for 16 months after CD34+-APBSCT. This appears to be the first case report of CD34+-APBSCT in a patient with CD30-negative cutaneous large T cell lymphoma. Bone Marrow Transplantation (2000) 25, 1315–1317.

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Acknowledgements

We thank Ms S Okazaki for assistance in preparing this manuscript. This work was supported by a Grant-in-Aid (08671204) from the Ministry of Education, Science, Sports and Culture of Japan, and by the Idiopathic Disorders of Hematopoietic Organs Research Committee supported by the Ministry of Health and Welfare, Japan.

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Authors and Affiliations

  1. Department of Internal Medicine II, Hokkaido University, School of Medicine, Sapporo, Japan

    M Nishio, K Koizumi, T Endo, H Takashima, Y Haseyama, K Fujimoto, S Yamamoto, T Koike & K Sawada

  2. Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan

    H Kobayashi

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  1. M Nishio
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  2. K Koizumi
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Nishio, M., Koizumi, K., Endo, T. et al. Effective high-dose chemotherapy combined with CD34+-selected autologous peripheral blood stem cell transplantation in a patient with cutaneous CD30-negative large T cell lymphoma. Bone Marrow Transplant 25, 1315–1317 (2000). https://doi.org/10.1038/sj.bmt.1702440

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  • DOI: https://doi.org/10.1038/sj.bmt.1702440

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