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Cunninghamella infection post bone marrow transplant: case report and review of the literature

Abstract

Cunninghamella spp., in the class Zygomycete and order Mucorales, are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Infections with this group of organisms have been seen most frequently in patients with hematologic malignancy. We describe an allogeneic bone marrow recipient who developed fungal pneumonitis and disseminated fungal dermatitis caused by Cunninghamella spp. To our knowledge, this is the first reported case of Cunninghamella infection in a BMT recipient. The case highlights the mortality associated with opportunistic infections in immunocompromised patients and confirms the risk factors associated with non-candida fungal infections after bone marrow transplantation. Bone Marrow Transplantation (2000) 25, 1213–1216.

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References

  1. Morrison VA, Haake RJ, Weisdorf DJ . Non-candida fungal infections after bone marrow transplantation: risk factors and Outcome Am J Med 1994 96: 497–503

    Article  CAS  Google Scholar 

  2. Morrison VA, Haake RJ, Weisdorf DJ . The spectrum of non-candida fungal infections following bone marrow transplantation Medicine 1993 72: 78–89

    Article  CAS  Google Scholar 

  3. Schell WA, Johnson MG, McGinnis MR et al. Zygomycosis caused by Cunninghamella bertholletiae: mycologic aspects Arch Pathol Lab Med 1982 106: 287–292

    CAS  PubMed  Google Scholar 

  4. Morrison VA, McGlave PB . Mucormycosis in the BMT population Bone Marrow Transplant 1993 11: 383–388

    CAS  PubMed  Google Scholar 

  5. Hutter RVP . Phycomycetous infection (mucormycosis) in cancer patients: a complication of therapy Cancer 1959 12: 330–350

    Article  CAS  Google Scholar 

  6. Zeilender S, Drenning D, Glauser FL, Bechard D . Fatal Cunninghamella bertholletiae infection in an immunocompetent patient Chest 1990 97: 1482–1483

    Article  CAS  Google Scholar 

  7. Cohen-Abbo A, Bozeman PM, Patrick CC . Cunninghamella infections: review and report of two cases of Cunninghamella pneumonia in immunocompromised children Clin Infect Dis 1993 17: 173–177

    Article  CAS  Google Scholar 

  8. Mazade MA, Margolin JF, Rossmann SN, Edwards MS . Survival from pulmonary infection with Cunninghamella bertholletiae: case report and review of the literature Ped Infec Dis J 1998 17: 835–839

    Article  CAS  Google Scholar 

  9. Boyce JM, Lawson LA, Lockwood WR, Hughes JL . Cunninghamella bertholletiae wound infection of probable nosocomial origin South Med J 1981 74: 1132–1135

    Article  CAS  Google Scholar 

  10. Sands JF, Macher AM, Ley TJ, Nienhuis AW . Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia Ann Intern Med 1985 102: 59–63

    Article  CAS  Google Scholar 

  11. Chetchotisakd P, Boonma P, Sookpranee M, Pairojkul C . Rhinocerebral mucormycosis: a report of eleven cases Southeast Asian J Trop Med Pub Health 1991 22: 268–273

    CAS  Google Scholar 

  12. Ng TT, Campbell CK, Rothera M et al. Successful treatment of sinusitis caused by Cunninghamella bertholletiae Clin Infect Dis 1994 19: 313–316

    Article  CAS  Google Scholar 

  13. Mostaza JM, Barbado FJ, Fernandez-Martin J et al. Cutaneoarticular mucormycosis due to Cunninghamella bertholletiae in a patient with AIDS Rev Infect Dis 1989 11: 316–318

    Article  CAS  Google Scholar 

  14. Bodey G . Dermatologic manifestations of infections in neutropenic patients Infect Dis Clin North Am 1994 8: 655–675

    CAS  PubMed  Google Scholar 

  15. Mowbray DN, Paller AS, Nelson PE, Kaplan RL . Disseminated Fusarium solani infection with cutaneous nodules in a bone marrow transplant patient Int J Dermatol 1988 27: 698–701

    Article  CAS  Google Scholar 

  16. Deeg HJ, Storb R . Graft-versus host disease: pathophysiological and clinical aspects Ann Rev Med 1984 35: 11–24

    Article  CAS  Google Scholar 

  17. Sale GE, Buckner CD . Pathology of bone marrow in transplant recipients Hematol/Oncol Clin North Am 1988 2: 735–756

    Article  CAS  Google Scholar 

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Darrisaw, L., Hanson, G., Vesole, D. et al. Cunninghamella infection post bone marrow transplant: case report and review of the literature. Bone Marrow Transplant 25, 1213–1216 (2000). https://doi.org/10.1038/sj.bmt.1702395

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