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Acute Leukaemia

Pediatric marrow transplantation for acute leukemia using unrelated donors and T-replete or -depleted grafts: a case-matched analysis

Bone Marrow Transplantation volume 25, pages 395–399 (2000)Cite this article

Abstract

A retrospective, case-matched analysis of the short-term toxicity, risk of GVHD and relapse as well as outcome in pediatric unrelated marrow transplantation was conducted by comparing recipients of T-replete and -depleted grafts in a two-center setting. Both groups contained 30 patients with acute leukemia matched by age at transplant, gender, primary diagnosis and disease status. Acute (90% vs 53%) and chronic (48% vs 0%) GVHD were more common among recipients of T-replete grafts. No significant differences in graft rejection/failure or viral infections were encountered between the two groups. Relapses were more prevalent (37% vs 15%) among recipients of T-depleted grafts. Outcome (EFS) was similar in the two groups. Consequently, in the analysis of transplant outcome, the higher risk of procedure-related, toxic complications among pediatric recipients of T-replete marrow grafts appears to be balanced by an increased risk of relapse among the recipients of T-depleted grafts. Bone Marrow Transplantation (2000) 25, 395–399.

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Acknowledgements

The financial support of the Nona and Kullervo Väre Foundation, Finland, is gratefully acknowledged.

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Authors and Affiliations

  1. Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland

    K Vettenranta, UM Saarinen-Pihkala & L Hovi

  2. Bone Marrow Transplantation Unit, Bristol Royal Hospital for Sick Children, Bristol, UK

    K Vettenranta, J Cornish, C Steward, D Pamphilon & A Oakhill

Authors
  1. K Vettenranta
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  2. UM Saarinen-Pihkala
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  3. J Cornish
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  4. C Steward
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  5. D Pamphilon
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  6. L Hovi
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  7. A Oakhill
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Vettenranta, K., Saarinen-Pihkala, U., Cornish, J. et al. Pediatric marrow transplantation for acute leukemia using unrelated donors and T-replete or -depleted grafts: a case-matched analysis. Bone Marrow Transplant 25, 395–399 (2000). https://doi.org/10.1038/sj.bmt.1702162

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  • DOI: https://doi.org/10.1038/sj.bmt.1702162

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