Abstract
Hemolytic uremic syndrome (HUS) after transplantation is difficult to treat, and there is no consensus regarding optimal mode of treatment. We attached transdermal isosorbide tape as a nitric oxide (NO) donor to patients with HUS after bone marrow transplantation (BMT). This was very effective in ameliorating the hemolysis and increasing platelet numbers. We report here the successful use of an isosorbide in a patient with HUS after transplantation. Bone Marrow Transplantation (2000) 25, 109–110.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chappell ME, Keeling DM, Prentice HG, Sweny P . Haemolytic uraemic syndrome after bone marrow transplantation: an adverse effect of total body irradiation? Bone Marrow Transplant 1988 3: 339–347
Guinan EC, Tarbell NJ, Niemeyer CM et al. Intravascular hemolysis and renal insufficiency after bone marrow transplantation Blood 1988 72: 451–455
Juckett M, Perry EH, Daniels BS, Weisdorf DJ . Hemolytic uremic syndrome following bone marrow transplantation Bone Marrow Transplant 1991 7: 405–409
Rabinowe SN, Soiffer RJ, Tarbell NJ et al. Hemolytic-uremic syndrome following bone marrow transplantation in adults for hematologic malignancies Blood 1991 77: 1837–1844
Oursler DP, Holley KE, Wagoner RD . Hemolytic uremic syndrome after bone marrow transplantation without total body irradiation Am J Nephrol 1993 13: 167–170
Lawton CA, Cohen EP, Barber-Derus SW et al. Late renal dysfunction in adult survivors of bone marrow transplantation Cancer 1991 67: 2795–2800
Ignarro LJ, Lippton H, Edwards JC et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates J Pharmacol Exp Ther 1981 218: 739–749
Chung SJ, Fung HL . Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development Biochem Pharmacol 1993 45: 157–163
Mulsch A, Mordvintcev P, Bassenge E et al. In vivo spin trapping of glyceryl trinitrate-derived nitric oxide in rabbit blood vessels and organs Circulation 1995 92: 1876–1882
Levin RI, Jaffe EA, Weksler BB, Tack-Goldman K . Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells J Clin Invest 1981 67: 762–769
Moncada S, Higgs EA, Vane JR . Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation Lancet 1977 1: 18–20
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kajiume, T., Nagita, A., Yoshimi, S. et al. A case of hemolytic uremic syndrome improved with nitric oxide. Bone Marrow Transplant 25, 109–110 (2000). https://doi.org/10.1038/sj.bmt.1702098
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702098
Keywords
This article is cited by
-
Hematopoietic stem cell transplant-associated thrombotic microangiopathy: current paradigm and novel therapies
Bone Marrow Transplantation (2018)
-
Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting?
Bone Marrow Transplantation (2007)
-
Transplantation-associated thrombotic microangiopathy: twenty-two years later
Bone Marrow Transplantation (2002)