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Normal Donor Follow-Up

Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor

Bone Marrow Transplantation volume 25, pages 85–89 (2000)Cite this article

Abstract

One hundred and one donors who had received filgrastim (rhG-CSF) for the purpose of donating either granulocytes or peripheral blood stem cells (PBSC) for their relatives more than 3 years ago were contacted. All donors had received daily rhG-CSF at a median dose of 16 μg/kg/day (range 3–16) for a median of 6 days (range 3–15 days). All collection procedures were completed and short-term side-effects of rhG-CSF were mild in the majority of the donors. At a median time interval of 43.13 months (range 35–73), the donors were contacted to assess whether adverse effects related to rhG-CSF administration had occurred. Prior to rhG-CSF two donors had cancer, one had a myocardial infarction, one was hepatitis C virus positive, one had a history of sinusitis, one had Graves’ disease and two had arterial hypertension. None worsened with the rhG-CSF administration but the donor with a history of infarction had an episode of angina following apheresis, and the donor with Graves’ disease had a stroke 15 months after rhG-CSF. Two pregnancies occurred after the rhG-CSF administration and one donor was 2–3 weeks pregnant during rhG-CSF treatment. Three pregnancies resulted in two normal births and one in a spontaneous abortion of a pregnancy which occurred more than 2 years following rhG-CSF. In the time following rhG-CSF administration two donors developed cancer (breast and prostate cancer) at a follow-up of 70 and 11 months, respectively. One donor developed lymphadenopathy 38 months after the rhG-CSF, which spontaneously resolved. Blood counts were obtained in 70 donors at a median follow up of 40.4 months (range 16.8–70.8). Hematocrit was 43% (median, range 36.8–48), white blood cells were 5.7 × 109/l (median, range 3–14), granulocytes 3.71 × 109/l (median, range 1.47–10.36), lymphocytes 1.67 × 109/l (median, range 0.90–3.96), monocytes 0.46 × 109/l (median, range 0.07–0.87) and platelet counts were 193.0 × 109/l (median, range 175.0–240.0). This study indicates that short-term administration of rhG-CSF to normal donors for the purpose of mobilizing the PBSC or granulocytes appears safe and without any obvious adverse effects more than 3 years after the donation. Bone Marrow Transplantation (2000) 25, 85–89.

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Acknowledgements

This work was supported by Grants: CA 18029, CA 47748, CA 18221, CA 15704, CA 09515, the Jose Carreras Foundation Against Leukemia, and the Joseph Steiner Fund.

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Authors and Affiliations

  1. Divisione di Ematologia, Unità Trapianti, Ospedale ‘V Cervello’, Palermo, Italy

    AM Cavallaro & I Majolino

  2. Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA

    K Lilleby, R Storb, FR Appelbaum, SD Rowley & WI Bensinger

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Cavallaro, A., Lilleby, K., Majolino, I. et al. Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor. Bone Marrow Transplant 25, 85–89 (2000). https://doi.org/10.1038/sj.bmt.1702072

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  • DOI: https://doi.org/10.1038/sj.bmt.1702072

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