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Chronic Myeloid Leukaemia

Mini-ICE regimen as mobilization therapy for chronic myelogenous leukaemia patients at diagnosis

Abstract

Between April 1996 and May 1998, 20 consecutive patients with Ph chromosome-positive CML in first chronic phase without an HLA-identical sibling received the mini-ICE regimen shortly after diagnosis to mobilize progenitor cells into the peripheral blood (PBPCs). The sex distribution was 12 males and eight females and the median (range) age 48.5 (22–62) years. The time interval between diagnosis and mobilization was a median (range) of 2 (0–5) months. Leukaphereses were initiated during recovery from chemotherapy-induced aplasia. A median number of 3 (1–7) aphereses per patient were performed to collect 2.0 × 106 CD34+cells/kg. Cytogenetic analysis was performed on the aphereses products of 18 patients. Complete cytogenetic Ph chromosome negativity was observed in four patients, nine had a partial negativity, three a minimal negativity and two no negative cells. Southern blot for bcr-abl was negative in the remaining two patients but the polymerase chain reaction analysis was positive. Following reinfusion, severe neutropenia was present for a median of 8.5 (3–19) days and severe thrombocytopenia lasted a median of 8 (3–18) days. Ten patients did not develop febrile neutropenia with four of them being treated on an outpatient basis. Treatment-related mortality was not observed. In conclusion, our experience demonstrates the feasibility of mobilizing PBPCs shortly after the diagnosis of CML with a safe regimen. Of note, mini-ICE allowed the collection of apheresis products with at least a major component of Ph-negative cells in almost 75% of the patients.

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Sureda, A., Petit, J., Brunet, S. et al. Mini-ICE regimen as mobilization therapy for chronic myelogenous leukaemia patients at diagnosis. Bone Marrow Transplant 24, 1285–1290 (1999). https://doi.org/10.1038/sj.bmt.1702068

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  • DOI: https://doi.org/10.1038/sj.bmt.1702068

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