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Successful treatment of Epstein–Barr virus-induced transverse myelitis with ganciclovir and cytomegalovirus hyperimmune globulin following unrelated bone marrow transplantation

Bone Marrow Transplantation volume 24, pages 1355–1358 (1999)Cite this article

Abstract

We report a patient who developed Epstein–Barr virus (EBV)-induced transverse myelitis 19 months after unrelated bone marrow transplantation (BMT). The disease was diagnosed by physical examination, serologic determinations, EBV-specific polymerase chain reaction in peripheral blood lymphocytes and cerebrospinal fluid, and characteristic magnetic resonance imaging scan of the spine. The patient was treated with ganciclovir and cytomegalovirus (CMV) hyperimmune globulin. He gradually improved and recovered completely within 4 weeks. This case suggests that ganciclovir and CMV hyperimmune globulin appear to be effective for the treatment of EBV-induced transverse myelitis in immunocompromised patients following BMT.

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Authors and Affiliations

  1. Department of Pediatrics, University of Jena, Jena, Germany

    B Gruhn, R Häfer, F Ringelmann, M Sauer, J Hermann & F Zintl

  2. Institute for Antiviral Chemotherapy, University of Jena, Jena, Germany

    A Meerbach

  3. Institute of Virology, University of Jena, Jena, Germany

    R Egerer

  4. Institute of Diagnostic and Interventional Radiology, University of Jena, Jena, Germany

    H-J Mentzel

Authors
  1. B Gruhn
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  2. A Meerbach
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  3. R Egerer
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  4. H-J Mentzel
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  5. R Häfer
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  6. F Ringelmann
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  7. M Sauer
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  8. J Hermann
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  9. F Zintl
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Gruhn, B., Meerbach, A., Egerer, R. et al. Successful treatment of Epstein–Barr virus-induced transverse myelitis with ganciclovir and cytomegalovirus hyperimmune globulin following unrelated bone marrow transplantation. Bone Marrow Transplant 24, 1355–1358 (1999). https://doi.org/10.1038/sj.bmt.1702057

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  • DOI: https://doi.org/10.1038/sj.bmt.1702057

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